Lack of vaccinia viremia after smallpox vaccination

被引：29
|
作者：
Cummings, JF
Polhemus, ME
Hawkes, C
Klote, M
Ludwig, GV
Wortmann, G
机构：
[1] Walter Reed Army Med Ctr, Div Infect Dis, Washington, DC 20307 USA
[2] Walter Reed Army Med Ctr, Div Allergy Immunol, Washington, DC 20307 USA
[3] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA
来源：
CLINICAL INFECTIOUS DISEASES | 2004年 / 38卷 / 03期
关键词：
D O I：
10.1086/381101
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Although the transmission of certain viral infections ( human immunodeficiency virus, hepatitis B and C viruses, and West Nile virus) through donated blood products is well described, the risk of transmitting vaccinia virus after smallpox vaccination is unknown. Blood samples from patients receiving the smallpox vaccine were obtained before vaccination; then from one-half of the study group on alternate days for each of the first 10 days after vaccination; then from all patients on days 14 and 21 after vaccination. Samples were analyzed by culture, polymerase chain reaction, and antigen detection ( electrochemiluminescence) assay for the presence of vaccinia virus. Two hundred and twenty samples from 28 volunteers were processed by all 3 laboratory detection methods and all were negative for the presence of vaccinia virus ( confidence interval, 0% - 12.3%). Viremia with vaccinia virus after smallpox vaccination appears to be an uncommon occurrence.
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收藏
页码：456 / 458
页数：3
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