No difference in survival between sporadic, familial and hereditary prostate cancer

Objective To estimate the survival of men with familial prostate cancer and compare them with prostate cancer cases unselected for family history. Patients and methods The overall and prostate cancer-specific survival was calculated in two large (249 and 304 men, respectively) population-based cohorts of men with familial prostate cancer. The tumour grade at diagnosis was also obtained in one of the cohorts. Results There were no significant differences in either overall or prostate cancer-specific survival between familial and sporadic cases. The spectrum of tumour grades at diagnosis in familial cases did not differ from that in a population with prostate cancer unselected for family history. Conclusion No differences in treatment between men with or without a positive family history of prostate cancer are instilled, based on the result from this study.