Collapsing glomerulopathy in a girl with systemic lupus erythematosus

被引：4
|
作者：
Tungekar, M. Fahim [2 ]
Waller, Simon [1 ]
Clothier, Joanna C. [1 ]
机构：
[1] Guys & St Thomas NHS Fdn Trust, Dept Paediat Nephrol, Evelina Childrens Hosp, London SE1 7EH, England
[2] Guys & St Thomas NHS Trust, Dept Histopathol, St Thomas Hosp, London, England
来源：
PEDIATRIC NEPHROLOGY | 2011年 / 26卷 / 05期
关键词：
Collapsing glomerulopathy; Collapsing variant FSGS; Systemic lupus erythematosus; Acute renal failure; Lupus nephritis;
D O I：
10.1007/s00467-010-1756-y
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Collapsing glomerulopathy has increasingly been recognised in patients with conditions other than HIV. The non-HIV form of collapsing glomerulopathy generally shows little response to standard therapies. We describe a 12-year-old girl with a pre-existing diagnosis of systemic lupus erythematosus presenting with renal failure. A renal biopsy gave the histological diagnosis of collapsing glomerulopathy with evidence of "full-house" immunostaining. We propose collapsing glomerulopathy in her case, as no other cause was found was secondary to systemic lupus erythematosus. The immunophenotype of her podocytes suggested a partial de-differentiation that might have been important in her partial response to immunosuppression.
引用
收藏
页码：809 / 813
页数：5
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