IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells

被引：0
|
作者：
Sweeney, C. M. [1 ,2 ]
Lonergan, R. [2 ]
Basdeo, S. A. [1 ]
Dungan, L. S. [1 ]
Kinsella, K. [2 ]
Costelloe, L. [2 ]
Tubridy, N. [2 ]
Fletcher, J. M. [1 ]
Mills, K. H. G. [1 ]
机构：
[1] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin, Ireland
[2] St Vincents Univ Hosp, Dept Neurol, Dublin 4, Ireland
来源：
IMMUNOLOGY | 2010年 / 131卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页码：36 / 36
页数：1
相关论文
共 50 条
  • [1] IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells
    Sweeney, Cheryl M.
    Lonergan, Roisin
    Basdeo, Sharee A.
    Kinsella, Katie
    Dungan, Lara S.
    Higgins, Sarah C.
    Kelly, Patrick J.
    Costelloe, Lisa
    Tubridy, Niall
    Mills, Kingston H. G.
    Fletcher, Jean M.
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (06) : 1170 - 1181
  • [2] The role of IFN-γ and IL-27 for Th17 plasticity in mouse CNS inflammation
    Wanke, Florian
    Moos, Sonja
    Heinen, Andre P.
    Firmenich, Stephanie
    Mueller, Werner
    Waisman, Ari
    Kurschus, Florian C.
    [J]. CYTOKINE, 2014, 70 (01) : 53 - 53
  • [3] Reciprocal interaction between NK cells and DCs regulates the Th17 response by controlling the innate IFN-γ/IL-27 axis
    Chong, Wai Po
    Chen, Jun
    Silver, Phyllis
    Caspi, Rachel
    [J]. JOURNAL OF IMMUNOLOGY, 2014, 192
  • [4] Reciprocal interaction between NK cells and DCs regulates the Th17 response by controlling the innate IFN-γ/IL-27 axis
    Caspi, Rachel
    Chen, Jun
    Silver, Phyllis
    Horai, R.
    Mattapallil, Mary
    Zhou, Ru
    Chong, WaiPo
    [J]. JOURNAL OF IMMUNOLOGY, 2013, 190
  • [5] NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis
    Chong, Wai Po
    van Panhuys, Nicholas
    Chen, Jun
    Silver, Phyllis B.
    Jittayasothorn, Yingyos
    Mattapallil, Mary J.
    Germain, Ronald N.
    Caspi, Rachel R.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2015, 212 (10): : 1739 - 1752
  • [6] Decreased expression of IL-27 and its correlation with Th1 and Th17 cells in progressive multiple sclerosis
    Tang, Shao-can
    Fan, Xiao-hua
    Pan, Qing-min
    Sun, Qiang-san
    Liu, Yu
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2015, 348 (1-2) : 174 - 180
  • [7] Reciprocal interaction between NK and DC regulates the autopathogenic Th17 response by controlling the innate IFN-γ/IL-27 axis
    Chong, Wai Po
    Chen, Jun
    Silver, Phyllis B.
    Horai, Reiko
    Mattapallil, Mary J.
    Zhou, Ru
    Caspi, Rachel R.
    [J]. CYTOKINE, 2013, 63 (03) : 254 - 254
  • [8] Independent and Interdependent Immunoregulatory Effects of IL-27, IFN-β, and IL-10 in the Suppression of Human Th17 Cells and Murine Experimental Autoimmune Encephalomyelitis
    Fitzgerald, Denise C.
    Fonseca-Kelly, Zoe
    Cullimore, Melissa L.
    Safabakhsh, Pegah
    Saris, Christiaan J. M.
    Zhang, Guang-Xian
    Rostami, Abdolmohamad
    [J]. JOURNAL OF IMMUNOLOGY, 2013, 190 (07): : 3225 - 3234
  • [9] A role for IFN-β in limiting TH17 cell accumulation in multiple sclerosis
    Galligan, Carole
    Rahbar, Ramtin
    Majchrzak, Beata
    Murooka, Thomas
    Baig, Ehtesham
    Fish, Eleanor
    [J]. CYTOKINE, 2008, 43 (03) : 244 - 244
  • [10] Expression of IL-27, Th1 and Th17 in Patients with Aplastic Anemia
    Hui-zhen Du
    Qian Wang
    Jian Ji
    Bao-ming Shen
    Shao-chun Wei
    Li-juan Liu
    Juan Ding
    Dao-xin Ma
    Wen Wang
    Jun Peng
    Ming Hou
    [J]. Journal of Clinical Immunology, 2013, 33 : 436 - 445
12345