WCC 7-Medication for the fast food nation: Bicyclo[2.2.2]octyltriazole inhibitors of 11 β-HSD1 for the treatment of metabolic syndrome

被引：0

作者：

Maletic, Milana ^{[1
]}

Leeman, Aaron ^{[1
]}

Waddell, Sherman T. ^{[1
]}

Balkovec, James M. ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Med Chem, Merck Res Labs, Rahway, NJ 07065 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 238卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

7-WCC

引用

页数：1

共 13 条

[1] Bicyclo[2.2.2]octyltriazole inhibitors of 11β-HSD1
Waddell, Sherman T.
Gu, Xin
Santorelli, Gina
Graham, Donald
Balkovec, James
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
[2] Bicyclo[2.2.2]octyltriazole inhibitors of 11beta-HSD1 are efficacious in animal models of metabolic disease
Waddell, Sherman T.
Maletic, Milana
Santorelli, Gina
Leeman, Aaron
Graham, Donald
Balkovec, James M.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 798 - 798
[3] Bicyclo[2.2.2] octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1:: Pharmacological agents for the treatment of metabolic syndrome
Maletic, Milana
Leeman, Aaron
Mundt, Steven S.
Zokian, Hratch J.
Shah, Kashmira
Dragovic, Jasminka
Lyons, Kathryn A.
Koprak, Sam L.
Koo, Gloria C.
Cheng, Kang
Tan, Eugene Y.
Thieringer, Rolf
Vosatka, Anne Hermanowski
Springer, Martin S.
Balkovec, James M.
Waddell, Sherman T.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
[4] Inhibitors of 11β-HSD1: A Potential Treatment for the Metabolic Syndrome
Jean, David J. St., Jr.
Wang, Minghan
Fotsch, Christopher
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, 8 (17) : 1508 - 1523
[5] Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome
Maletic, Milana
Leeman, Aaron
Szymonifka, Michael
Mundt, Steven S.
Zokian, Hratch J.
Shah, Kashmira
Dragovic, Jasminka
Lyons, Kathy
Thieringer, Rolf
Vosatka, Anne H.
Balkovec, James
Waddell, Sherman T.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (08) : 2568 - 2572
[6] MEDI 229-Bicyclo[2.2.2]octyltriazole inhibitors of 11beta-HSD1 are efficacious in animal models of metabolic disease
Murray, Desmond H.
Lange, Linda
Matak, Andrija A.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 914 - 914
[7] Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome
Richards, Steven
Sorensen, Bryan
Jae, Hwan-Soo
Winn, Marty
Chen, Yixian
Wang, Jiahong
Fung, Steven
Monzon, Katina
Frevert, Ernst U.
Jacobson, Peer
Sham, Hing
Link, J. T.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (24) : 6241 - 6245
[8] Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1:: Novel therapeutic agents for the treatment of metabolic syndrome
Gu, X
Dragovic, J
Koo, GC
Koprak, SL
LeGrand, C
Mundt, SS
Shah, K
Springer, MS
Tan, EY
Thieringer, R
Hermanowski-Vosatka, A
Zokian, HJ
Balkovec, JM
Waddell, ST
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (23) : 5266 - 5269
[9] Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors for the treatment of metabolic disorders
Yoon, David S.
Wu, Shung C.
Seethala, Ramakrishna
Golla, Rajasree
Nayeem, Akbar
Everlof, John G.
Gordon, David A.
Hamann, Lawrence G.
Robl, Jeffrey A.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (21) : 5045 - 5049
[10] MEDI 53-Synthesis and biologic evaluation of selective inhibitors of 11β-HSD1 as a potential treatment for metabolic disorders
Neelamkavil, Santhosh F.
Boyle, Craig D.
Chackalamannil, Samuel
Baker, Hana
Kowalski, Timothy
Zhang, Lili
Terracina, Giuseppe
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234

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