Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients

被引：7

作者：

Bajpai, Meenu ^{[1
]}

Maheshwari, Ashish ^{[1
]}

Kumar, Suresh ^{[2
]}

Chhabra, Karan ^{[2
]}

Kale, Pratibha ^{[3
]}

Narayanan, Ashad ^{[4
]}

Gupta, Amita ^{[1
]}

Gupta, Ekta ^{[5
]}

Trehanpati, Nirupama ^{[5
]}

Agarwal, Reshu ^{[6
]}

Gupta, Kamini ^{[6
]}

Bhardwaj, Ankit ^{[7
]}

Islam, Mojahidul ^{[5
]}

Singh, Ravinder ^{[5
]}

Yadav, Pushpa ^{[5
]}

Kumar, Guresh ^{[8
]}

Sarin, Shiv K. ^{[4
]}

机构：

[1] Inst Liver & Biliary Sci, Dept Transfus Med, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[2] Lok Nayak Jai Prakash Hosp, Dept Med, Maulana Azad Med Coll Campus, J6QP PRR,Jawaharlal Nehru Marg, Delhi 110002, India

[3] Inst Liver & Biliary Sci, Dept Microbiol, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[4] Inst Liver & Biliary Sci, Dept Hepatol, D1 Ilbs,D-1,Vast Kunj Rd, Delhi 110070, India

[5] Inst Liver & Biliary Sci, Dept Mol & Cellular Med, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[6] Inst Liver & Biliary Sci, Dept HepatoVirol, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[7] Inst Liver & Biliary Sci, Dept Clin Res, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[8] Inst Liver & Biliary Sci, Dept Res, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2022年 / 94卷 / 04期

关键词：

COVID-19; convalescent plasma; donor plasmapheresis; ARDS; immunoglobulins; antibodies;

D O I：

10.1590/0001-3765202220210202

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

background: Role of Convalescent plasma (COPLA) to treat severe COVID-19 is under investigation. We compared efficacy and safety of COPLA with fresh frozen plasma (FFP) in severe COVID-19 patients. Methods: One group received COPLA with standard medical care (n = 14), and another group received random donor FFP, as control with standard medical care (n = 15) in severe COVID-19 disease. Results: The proportion of patients free of ventilation at day seven were 78.5% in COPLA group, and 93.3 % in control group were not significant (p= 0.258). However, improved respiratory rate, O2 saturation, SOFA score, and Ct value were observed in the COPLA group. No serious adverse events were noticed by plasma transfusion in both groups.

引用

页数：8

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