Squarate Cross-Linked Gelatin Hydrogels as Three-Dimensional Scaffolds for Biomedical Applications

被引：7

作者：

Stucchi, Simone ^{[1
,2
]}

Colombo, Danilo ^{[1
,3
]}

Guizzardi, Roberto ^{[1
,4
]}

D'Aloia, Alessia ^{[1
]}

Collini, Maddalena ^{[5
,6
]}

Bouzin, Margaux ^{[5
]}

Costa, Barbara ^{[1
]}

Ceriani, Michela ^{[1
]}

Natalello, Antonino ^{[1
]}

Pallavicini, Piersandro ^{[7
]}

Cipolla, Laura ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, I-20126 Milan, Italy

[2] Univ N Carolina, Chapel Hill, NC 27515 USA

[3] Politecn Milan, Dept Chem Mat & Chem Engn Giulio Natta, Via Mancinelli 7, I-20131 Milan, Italy

[4] Tecnoservizi Ambientali Srl, Romano Di Lombardia, Italy

[5] Univ Milano Bicocca, Dept Phys Giuseppe Occhialini, I-20126 Milan, Italy

[6] Univ Milano Bicocca, Nanomed Ctr, I-20126 Milan, Italy

[7] Univ Pavia, Dept Chem, I-27100 Pavia, Italy

来源：

LANGMUIR | 2021年 / 37卷 / 48期

关键词：

CELL; SPECTROSCOPY; DIFFUSION; MATRIX; ACID;

D O I：

10.1021/acs.langmuir.1c02080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrogels are useful platforms as three-dimensional (3D) scaffolds for cell culture, drug-release systems, and regenerative medicine applications. Here, we propose a novel chemical cross-linking approach by the use of 3,4-diethoxy-3-cyclobutene-1,2-dione or diethyl squarate for the preparation of 5 and 10% w/v gelatin-based hydrogels. Hydrogels showed good swelling properties, and the 5% gelatin-based hydrogel proved suitable as a 3D cell culture scaffold for the chondrocyte cell line C28/I2. In addition, diffusion properties of different sized molecules inside the hydrogel were determined.

引用

页码：14050 / 14058

页数：9

共 50 条

[1] Squarate Cross-Linked Gelatin Hydrogels as Three-Dimensional Scaffolds for Biomedical Applications
Cipolla, Laura (laura.cipolla@unimib.it), 1600, American Chemical Society (37):
[2] Photochemically cross-linked collagen gels as three-dimensional scaffolds for tissue engineering
Ibusuki, Shinichi
Halbesma, Gerrit J.
Randolph, Mark A.
Redmond, Robert W.
Kochevar, Irene E.
Gill, Thomas J.
TISSUE ENGINEERING, 2007, 13 (08): : 1995 - 2001
[3] Modified dextran cross-linked electrospun gelatin nanofibres for biomedical applications
Jalaja, K.
Kumar, P. R. Anil
Dey, Tuli
Kundu, Subhas C.
James, Nirmala R.
CARBOHYDRATE POLYMERS, 2014, 114 : 467 - 475
[4] Modified gum arabic cross-linked gelatin scaffold for biomedical applications
Sarika, P. R.
Cinthya, Kuriakose
Jayakrishnan, A.
Anilkumar, P. R.
James, Nirmala Rachel
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2014, 43 : 272 - 279
[5] Engineering of nanometer-sized cross-linked hydrogels for biomedical applications
Oh, Jung Kwon
CANADIAN JOURNAL OF CHEMISTRY, 2010, 88 (03) : 173 - 184
[6] Chondroitin sulfate cross-linked three-dimensional tailored electrospun scaffolds for cartilage regeneration
Chen, Yujie
Xu, Wei
Shafiq, Muhammad
Song, Daiying
Xie, Xianrui
Yuan, Zhengchao
EL-Newehy, Mohamed
EL-Hamshary, Hany
Morsi, Yosry
Liu, Yu
Mo, Xiumei
BIOMATERIALS ADVANCES, 2022, 134
[7] Synthesis of cross-linked tannin-gelatin hydrogels
Osetrov, K. O.
Uspenskaya, M. V.
Olekhnovich, R. O.
Strelnikova, I. E.
RUSSIAN CHEMICAL BULLETIN, 2022, 71 (03) : 557 - 563
[8] Synthesis of cross-linked tannin-gelatin hydrogels
K. O. Osetrov
M. V. Uspenskaya
R. O. Olekhnovich
I. E. Strelnikova
Russian Chemical Bulletin, 2022, 71 : 557 - 563
[9] Hydrogels Based on Proteins Cross-Linked with Carbonyl Derivatives of Polysaccharides, with Biomedical Applications
Mahmoudi, Chahrazed
Douma, Naima Tahraoui
Mahmoudi, Hacene
Iurciuc , Camelia Elena
Popa, Marcel
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (14)
[10] Biomimetic Alginate/Gelatin Cross-Linked Hydrogels Supplemented with Polyphosphate for Wound Healing Applications
Wang, Shunfeng
Wang, Xiaohong
Neufurth, Meik
Tolba, Emad
Schepler, Hadrian
Xiao, Shichu
Schroeder, Heinz C.
Mueller, Werner E. G.
MOLECULES, 2020, 25 (21):

← 1 2 3 4 5 →