New chloroamide- steroid derivative with biological activity on a casein kinase 2 (CK2)

被引：0
|
作者：
Lauro, Figueroa-Valverde [2 ]
Abelardo, Camacho-Luis
Alejandara, Garcimarrero E. [1 ]
Marcela, Rosas-Nexticapa [3 ]
Maria Virginia, Mateu-Armad [3 ]
Rolando, Garcia-Martinez [1 ]
Francisco, Diaz-Cedillo [4 ]
Maria, Lopez-Ramos [5 ]
Regina, Cauich-Carrillo [1 ]
Marin-Parra, A. [3 ]
Raquel, Estrella-Barron [5 ]
机构：
[1] Univ Autonomous Campeche, Lab Pharmacochem, Fac Chem Biol Sci, Av Agustin Melgar S-N, Camp 24039, Campeche, Mexico
[2] Univ Veracruzana, Fac Med, Unidad Bosque, Med & Odontologos S-N, Xalapa 91010, Veracruz, Mexico
[3] Univ Veracruzana, Fac Nutr, Unidad Bosque, Med & Odontologos S-N, Xalapa 91010, Veracruz, Mexico
[4] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Prol Carpio y Plan de Ayala S-N, Mexico City 11340, DF, Mexico
[5] Univ Autonoma Carmen, Fac Ciencias Salud Campus 3, Av Cent S-N, Ciudad del Carmen 24153, Campeche, Mexico
来源：
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2020年 / 10卷 / 02期
关键词：
Synthesis; steroid; derivative; casein kinase 2; PROTEIN-KINASE; ISCHEMIA-REPERFUSION; SELECTIVE REDUCTION; NITRO-COMPOUNDS; SIGNAL-TRANSDUCTION; INHIBITOR; CHLORINATION; ACTIVATION; COMPLEX; POTENT;
D O I：
10.33263/BRIAC102.145155
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Several casein kinase 2 inhibitors have been prepared using some protocols which require dangerous reagents and specific conditions. The aim of this study was to synthesize a new chloroacetamide-steroid derivative using some chemical tools. In addition, the effect exerted by chloroacetamide-steroid derivative on casein kinase 2 (CK2) was determinate in an ischemia-reperfusion injury model using quinalizarin and N-tertbuthyl-2-chloroacetamide as controls. The results showed that 1) the chloroacetamide-steroid derivative significantly decrease the ischemia-reperfusion injury translated as infarct area compared with quinalizarin and N-tertbuthyl-2chloroacetamide. In conclusion, in this study, is reported a facile synthesis of a new chloroacetamide-steroid derivative with biological activity against CK2.
引用
收藏
页码：5145 / 5155
页数：11
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