Alterations of calcium homeostasis in cancer cells

被引：91
|
作者：
Marchi, Saverio [1 ]
Pinton, Paolo [1 ]
机构：
[1] Univ Ferrara, Lab Technol Adv Therapies LTTA, Sect Pathol Oncol & Expt Biol, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy
来源：
CURRENT OPINION IN PHARMACOLOGY | 2016年 / 29卷
关键词：
INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; HUMAN PROSTATE-CANCER; ENDOPLASMIC-RETICULUM; REGULATES APOPTOSIS; TUMOR-METASTASIS; PLASMA-MEMBRANE; DOWN-REGULATION; CA2+ RELEASE; BH4; DOMAIN; BCL-2;
D O I：
10.1016/j.coph.2016.03.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Typical hallmarks of cancer include programmed cell death evasion, uncontrolled cell growth, invasion, and metastasis. Changes in intracellular Ca2+ levels can modulate signaling pathways that control a broad range of cellular events, including those important to tumorigenesis and cancer progression. Here we discuss how known molecular mediators of cellular Ca2+ homeostasis impact tumor dynamics and how deregulation of major oncogenes and tumor suppressors is tightly associated with Ca2+ signaling.
引用
收藏
页码：1 / 6
页数：6
相关论文
共 50 条
  • [1] Alterations in the calcium homeostasis and regulatory volume decrease associated with neuroendocrine differentiation of prostate cancer epithelial cells
    Skryma, R
    Lemonnier, L
    Shuba, Y
    [J]. BIOPHYSICAL JOURNAL, 2005, 88 (01) : 612A - 613A
  • [2] Alterations of calcium homeostasis affect the survival of human retinal epithelial cells
    Yeung, CK
    Chan, KP
    Chiang, SWY
    Pang, CP
    Ko, WH
    Lam, DSC
    [J]. JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, 2004, 23 (02): : 135 - 147
  • [3] ALTERATIONS IN CALCIUM HOMEOSTASIS IN THE AGED BRAIN
    WALSH, JP
    OU, X
    VILLAR, FAS
    [J]. JOURNAL OF NEUROCHEMISTRY, 1994, 62 : S26 - S26
  • [4] Alterations of calcium homeostasis in single smooth muscle cells of spontaneously hypertensive rats
    Kreiner, A
    Schubert, R
    Hopp, HH
    Pfeiffer, C
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1997, 433 (06): : P280 - P280
  • [5] ALTERATIONS OF INVIVO BRAIN CALCIUM HOMEOSTASIS WITH AGING
    GIBSON, G
    PERRINO, P
    DIENEL, G
    [J]. AGE, 1984, 7 (04) : 148 - 149
  • [6] The Antiproliferative Effect of EPA in HL60 Cells is Mediated by Alterations in Calcium Homeostasis
    Slagsvold, Jens Erik
    Pettersen, Caroline Hild Hakvag
    Follestad, Turid
    Krokan, Hans Einar
    Schonberg, Svanhild Arentz
    [J]. LIPIDS, 2009, 44 (02) : 103 - 113
  • [7] Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells
    Kania, Elzbieta
    Pajak, Beata
    Orzechowski, Arkadiusz
    [J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015
  • [8] In vitro findings of alterations in intracellular calcium homeostasis in schizophrenia
    Bojarski, Lukasz
    Debowska, Katarzyna
    Wojda, Urszula
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2010, 34 (08): : 1367 - 1374
  • [9] Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells
    Aung, Cho S.
    Ye, Weilan
    Plowman, Greg
    Peters, Amelia A.
    Monteith, Gregory R.
    Roberts-Thomson, Sarah J.
    [J]. CARCINOGENESIS, 2009, 30 (11) : 1962 - 1969
  • [10] Fenvalerate-induced Alterations in Calcium Homeostasis in Rat Ovary
    JUN HE
    [J]. Biomedical and Environmental Sciences, 2006, (01) : 15 - 20
12345