A new simple route to N-substituted 2-aminoethylphosphonic acids

被引：19

作者：

Fu, XK ^{[1
]}

Gong, CB ^{[1
]}

Ma, XB ^{[1
]}

Wen, SY ^{[1
]}

机构：

[1] SW China Normal Univ, Coll Chem & Chem Engn, Chongqing 400715, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 14期

关键词：

D O I：

10.1080/00397919808004835

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Aminoethylphosphonic acid (AEPA) and its N-substituted compounds were prepared by one step reaction using 2-chloroethylphosphonic acid with ammonia and amines (H2NMe, HNMeMe, HMEtEt, H2NPr-n, H(2)NCH(2)ph,H2NCH2CH2NH2 and H2N(C=NII)NH2 in a dilute alkaline solution below 20 degrees C with simple work-up and easy purification. The reaction was accelerated by catalytic amount of potassium iodide. The yield for the reaction products were 35.6 to 48.6% for the KI absence and 78.2 to 88.0% for the KI presence.

引用

页码：2659 / 2664

页数：6

共 50 条

[1] Comments on a new simple route to N-substituted 2-aminoethylphosphonic acids.: A reinvestigation
Soroka, M
Stochaj, M
[J]. SYNTHETIC COMMUNICATIONS, 2003, 33 (21) : 3781 - 3788
[2] SIMPLE SYNTHESIS OF 2-AMINOETHYLPHOSPHONIC ACID AND RELATED COMPOUNDS
BARYCKI, J
MASTALER.P
SOROKA, M
[J]. TETRAHEDRON LETTERS, 1970, (36) : 3147 - &
[3] A NEW ROUTE TO N-SUBSTITUTED AMINOMETHYLPHOSPHONATES
HA, HJ
NAM, GS
PARK, KP
[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 1990, 11 (06): : 485 - 486
[4] A NEW ROUTE TO N-SUBSTITUTED HETEROCYCLES
KATRITZKY, AR
LANG, HY
LAN, XF
[J]. TETRAHEDRON, 1993, 49 (14) : 2829 - 2838
[5] ESTERS OF N-SUBSTITUTED BETA-AMINOETHYLPHOSPHONIC ACID
GUBNITSKAYA, ES
PERESYPKINA, LP
[J]. ZHURNAL OBSHCHEI KHIMII, 1989, 59 (03): : 556 - 564
[6] A new route for the synthesis of N-substituted diketopiperazine derivatives
Gong, X
Yang, XX
Wang, DX
[J]. CHINESE CHEMICAL LETTERS, 2006, 17 (04) : 469 - 472
[7] A new synthetic route to authentic N-substituted aminomaleimides
Conley, NR
Hung, RJ
Willson, CG
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (11): : 4553 - 4555
[8] A New Route for the Synthesis of N-Substituted Diketopiperazine Derivatives
Xi GONG
[J]. Chinese Chemical Letters, 2006, (04) : 469 - 472
[9] A new route to N-substituted 11-azaartemisinins
Mekonnen, B
Ziffer, H
[J]. TETRAHEDRON LETTERS, 1997, 38 (05) : 731 - 734
[10] A NEW ROUTE TO N-SUBSTITUTED O-PHENYLENEDIAMINES
LANE, ES
WILLIAMS, C
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1955, : 1468 - 1470

← 1 2 3 4 5 →