Asymmetric pinacol coupling of aromatic aldehydes with TiCl2/enantiopure amine or hydrazine reagents

被引：45
|
作者：
Enders, D [1 ]
Ullrich, EC [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
来源：
TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 19期
关键词：
D O I：
10.1016/S0957-4166(00)00379-7
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Asymmetric pinacol coupling of aromatic aldehydes under homogeneous conditions with TiCl2 in the presence of enantiopure amines or hydrazines afforded 1,2-diols in moderate to excellent yields with good dl-diastereoselectivities and enantioselectivities in the range of 6-65% ee. A non-linear temperature effect ('principle of isoinversion') has been examined. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：3861 / 3865
页数：5
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