Identificatio of aurintricarboxylic acid as a potent allosteric antagonist of P2X3 receptors

被引:0
|
作者
Obrecht, A. [1 ]
Kless, A. [2 ]
Meents, J. E. [1 ]
Urban, N. [3 ]
Schaefer, M. [3 ]
Lampert, A. [1 ]
Schmalzing, G. [4 ]
Hausmann, R. [5 ]
机构
[1] Univ Hosp RWTH Aachen, Dept Plast Surg Hand & Burn Surg, Aachen, Germany
[2] Grunenthal GmbH, Grunenthal Innovat, Dept Translat Sci & Intelligence, Aachen, Germany
[3] Univ Leipzig, Rudolf Boehm Inst Pharmacol & Toxicol, Leipzig, Germany
[4] Rhein Westfal TH Aachen, Mol Pharmacol, Aachen, Germany
[5] Rhein Westfal TH Aachen, Inst Clin Pharmacol, Aachen, Germany
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
21
引用
收藏
页码:7 / 7
页数:1
相关论文
共 50 条
  • [1] Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors
    Obrecht, Astrid S.
    Urban, Nicole
    Schaefer, Michael
    Roese, Anni
    Kless, Achim
    Meents, Jannis E.
    Lampert, Angelika
    Abdelrahman, Aliaa
    Mueller, Christa E.
    Schmalzing, Gunther
    Hausmann, Ralf
    NEUROPHARMACOLOGY, 2019, 158
  • [2] High-throughput screening of approved drugs and bioactive compounds identifies aurintricarboxylic acid as a nanomolar potent antagonist of the P2X3 receptor
    Obrecht, A.
    Urban, N.
    Schaefer, M.
    Schmalzing, G.
    Hausmann, R.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2017, 390 : S42 - S42
  • [3] Druggable negative allosteric site of P2X3 receptors
    Wang, Jin
    Wang, Yao
    Cui, Wen-Wen
    Huang, Yichen
    Yang, Yang
    Liu, Yan
    Zhao, Wen-Shan
    Cheng, Xiao-Yang
    Sun, Wang-Sheng
    Cao, Peng
    Zhu, Michael X.
    Wang, Rui
    Hattori, Motoyuki
    Yu, Ye
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (19) : 4939 - 4944
  • [4] Potent desensitization of human P2X3 receptors by diadenosine polyphosphates
    McDonald, HA
    Chu, KL
    Bianchi, BR
    McKenna, DG
    Briggs, CA
    Burgard, EC
    Lynch, KJ
    Faltynek, C
    Cartmell, J
    Jarvis, MF
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 435 (2-3) : 135 - 142
  • [5] Allosteric modulation and accelerated resensitization of human P2X3 receptors by cibacron blue
    Alexander, K
    Niforatos, W
    Bianchi, B
    Burgard, EC
    Lynch, KJ
    Kowaluk, EA
    Jarvis, MF
    van Biesen, T
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1999, 291 (03): : 1135 - 1142
  • [6] AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
    Gever, Joel R.
    Soto, Rothschild
    Henningsen, Robert A.
    Martin, Renee S.
    Hackos, David H.
    Panicker, Sandip
    Rubas, Werner
    Oglesby, Ian B.
    Dillon, Michael P.
    Milla, Marcos E.
    Burnstock, Geoffrey
    Ford, Anthony P. D. W.
    BRITISH JOURNAL OF PHARMACOLOGY, 2010, 160 (06) : 1387 - 1398
  • [7] A-317491, a novel potent and selective nonnucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
    Jarvis, MF
    Burgard, EC
    McGaraughty, S
    Honore, P
    Lynch, K
    Brennan, TJ
    Subieta, A
    van Biesen, T
    Cartmell, J
    Bianchi, B
    Niforatos, W
    Kage, K
    Yu, HX
    Mikusa, J
    Wismer, CT
    Zhu, CZ
    Chu, K
    Lee, CH
    Stewart, AO
    Polakowski, J
    Cox, BF
    Kowaluk, E
    Williams, M
    Sullivan, J
    Faltynek, C
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (26) : 17179 - 17184
  • [8] Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors
    Jung, Young-Hwan
    Kim, Yeo Ok
    Lin, Hai
    Cho, Joong-Heui
    Park, Jin-Hee
    Lee, So-Deok
    Bae, Jinsu
    Kang, Koon Mook
    Kim, Moon-Gyoon
    Pae, Ae Nim
    Ko, Hyojin
    Park, Chul-Seung
    Yoon, Myung Ha
    Kim, Yong-Chul
    ACS CHEMICAL NEUROSCIENCE, 2017, 8 (07): : 1465 - 1478
  • [9] A Single Amino Acid Mutation Turns a P2X3 Antagonist into an Agonist
    Wang, Jixin
    Moore, Eric
    Kane, Stefanie
    Salvatore, Christopher
    Cook, Sean
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 485A - 485A
  • [10] Discovery of potent antiallodynic agents for neuropathic pain targeting P2X3 receptors
    Jung, Young-Hwan
    Kim, Yeo Ok
    Lin, Hai
    Cho, Joong-Heui
    Park, Jin-Hee
    Lee, So-Deok
    Bae, Jinsu
    Kang, Koon Mook
    Kim, Yoon-Gyoon
    Pae, Ae Nim
    Ko, Hyojin
    Park, Chul-Seung
    Yoon, Myung Ha
    Kim, Yong-Chul
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254