Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease

被引：191
|
作者：
Reitz, Christiane [1 ,2 ,3 ]
Tang, Ming-Xin [1 ,6 ]
Schupf, Nicole [1 ,2 ,5 ,7 ]
Manly, Jennifer J. [1 ,2 ,3 ]
Mayeux, Richard [1 ,2 ,3 ,5 ,7 ]
Luchsinger, Jose A. [1 ,2 ,4 ]
机构：
[1] Columbia Univ Coll Phys & Surg, Mailman Sch Publ Hlth, Gertrude H Sergievsky Ctr, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Mailman Sch Publ Hlth, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA
[3] Columbia Univ Coll Phys & Surg, Mailman Sch Publ Hlth, Dept Neurol, New York, NY 10032 USA
[4] Columbia Univ Coll Phys & Surg, Mailman Sch Publ Hlth, Dept Med, New York, NY 10032 USA
[5] Columbia Univ Coll Phys & Surg, Mailman Sch Publ Hlth, Dept Psychiat, New York, NY 10032 USA
[6] Columbia Univ Coll Phys & Surg, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA
[7] Columbia Univ Coll Phys & Surg, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA
来源：
ARCHIVES OF NEUROLOGY | 2010年 / 67卷 / 12期
关键词：
MILD COGNITIVE IMPAIRMENT; CORONARY-HEART-DISEASE; APOLIPOPROTEIN-A-I; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; VASCULAR DEMENTIA; PLASMA-LIPIDS; REDUCED RISK; DIAGNOSIS; HDL;
D O I：
10.1001/archneurol.2010.297
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models. Design: Prospective cohort study. Setting: Northern Manhattan, New York. Participants: One thousand one hundred thirty elderly individuals free of cognitive impairment at baseline. Main Outcome Measure: High-density lipoprotein cholesterol (HDL-C) levels. Results: Higher levels of HDL-C (>55 mg/dL) were associated with a decreased risk of both probable and possible AD and probable AD compared with lower HDL-C levels (hazard ratio, 0.4; 95% confidence interval, 0.20.9; P=.03 and hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P=.03). In addition, higher levels of total and non HDL-C were associated with a decreased risk of AD in analyses adjusting for age, sex, education, ethnic group, and APOEe4 genotype. Conclusion: High HDL-C levels in elderly individuals may be associated with a decreased risk of AD.
引用
收藏
页码：1491 / 1497
页数：7
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