Lyophilization in vials on trays: Effects of tray side

被引：25

作者：

Gan, KH

Crosser, OK

Liapis, AI ^{[1
]}

机构：

[1] Univ Missouri, Dept Chem, Rolla, MO 65409 USA

[2] Univ Missouri, Dept Biol Engn, Rolla, MO USA

[3] Univ Missouri, Biochem Proc Inst, Rolla, MO USA

[4] Criofarma Freeze Drying Equipment, Turin, Italy

来源：

DRYING TECHNOLOGY | 2005年 / 23卷 / 1-2期

关键词：

distribution of concentration of bound water; distribution of temperature; drying times; freeze drying in vials; heating policies; height of tray side; hexagonal arrays of vials; lyophilization in vials; velocity of moving sublimation interface;

D O I：

10.1081/DRT-200047671

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The effects of tray side on the performance of lyophilization of pharmaceuticals in vials arranged in Clusters of hexagonal arrays on trays are studied and the results of this work indicate that it would be beneficial to operate the freeze drying process by employing freeze dryers whose trays have no tray sides and using heat input control that runs the lyophilization process close to the melting and scorch temperature constraints during the primary and secondary drying stages, respectively.

引用

页码：341 / 363

页数：23

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