High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas

被引：24
|
作者：
Iyevleva, Aglaya G. [1 ,2 ]
Kuligina, Ekatherina Sh [1 ]
Mitiushkina, Nathalia V. [1 ]
Togo, Alexandr V. [1 ]
Miki, Yoshio [3 ]
Imyanitov, Evgeny N. [1 ,2 ,4 ]
机构：
[1] NN Petrov Inst Oncol, Mol Oncol Lab, St Petersburg 197758, Russia
[2] St Petersburg Pediat Med Acad, Dept Med Genet, St Petersburg, Russia
[3] Japanese Fdn Canc Res, Inst Canc, Dept Genet Diag, Tokyo 170, Japan
[4] St Petersburg Med Acad Postgrad Studies, Dept Oncol, St Petersburg, Russia
来源：
BREAST CANCER RESEARCH AND TREATMENT | 2012年 / 131卷 / 03期
关键词：
microRNA; Bilateral breast cancer; Breast cancer predisposition; CANCER CELL-LINES; RT-PCR; TARGETS; TUMOR; INVASION; MICRORNA-155; GROWTH; GENE; MALIGNANCIES; CONCORDANCE;
D O I：
10.1007/s10549-011-1845-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We analyzed the expression of several microRNAs (miRs) implicated in breast cancer (BC) pathogenesis (miR-21, miR-10b, miR17-5p, mir-31, miR-155, miR-200c, miR-18a, miR-205, and miR-27a) in 80 breast carcinomas obtained from patients with bilateral BC (biBC) and 40 cases of unilateral BC (uBC). Unexpectedly, three miRs (miR-21, miR-10b and miR-31) demonstrated significantly higher level of expression in biBC vs. uBC (P = 0.0001, 0.00004 and 0.0002, respectively). Increased contents of miR-21, miR-10b and miR-31 were observed in all categories of biBC tumors, i.e., in synchronous biBC as well as in first and second tumors from metachronous biBC cases. Synchronous biBC showed more similarity of miR expression profiles within pairs that the metachronous doublets (P = 0.004). This study suggests that bilateral breast tumors have somewhat distinct pattern of molecular events as compared to the unilateral disease.
引用
收藏
页码：1049 / 1059
页数：11
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