Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case-control study using a national sample cohort

IntroductionThe previous studies suggested an association between osteoporosis and sudden sensory neural hearing loss (SSNHL). The aim of the present study was to evaluate the association between osteoporosis and benign paroxysmal positional vertigo (BPPV).Materials and methodsData from the Korean National Health Insurance Service-National Sample Cohort of participants who were 50years old were collected from 2002 to 2013. A total of 13,484 BPPV participants were matched with respect to age group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia to 53,936 controls. In both the BPPV and control groups, the previous histories of osteoporosis were evaluated. Crude (simple) and adjusted odds ratios (ORs) of osteoporosis for BPPV were analyzed using unconditional logistic regression analyses. Subgroup analyses were conducted according to age, sex, and BPPV frequency.ResultsA total of 18.64% (2514/13,464) of the BPPV group and 12.21% (6589/53,936) of the control group had a history of osteoporosis (P<0.001). The adjusted OR of osteoporosis for BPPV was 1.29 (95% CI=1.23-1.35, P<0.001). In the subgroup analysis according to age and sex, the 70-year-old men did not demonstrate a high adjusted OR of osteoporosis for BPPV. All other age and sex subgroups demonstrated high adjusted ORs of osteoporosis for BPPV.ConclusionsOsteoporosis increased the risk of BPPV in the population aged50years. The OR of osteoporosis was higher in the frequent BPPV group than in the less frequent BPPV group.