Mechanism of action of herbs and their active constituents used in hair loss treatment

被引：55
|
作者：
Herman, Anna [1 ]
Herman, Andrzej P. [2 ]
机构：
[1] Acad Cosmet & Hlth Care, Fac Cosmetol, Podwale 13 St, PL-00252 Warsaw, Poland
[2] Polish Acad Sci, Kielanowski Inst Anim Physiol and`Nutr, Mol Biol Lab, Instytucka 3 St, PL-05110 Jablonna, Poland
来源：
FITOTERAPIA | 2016年 / 114卷
关键词：
Herbs; Herbs active constituents; Hair loss; Hair growth; Mechanism of action; EPIDERMAL-GROWTH-FACTOR; FACTOR-I PRODUCTION; ALOPECIA-AREATA; ANDROGENETIC ALOPECIA; TOPICAL APPLICATION; FACTOR VEGF; FOLLICLE; MICE; EXTRACT; DIFFERENTIATION;
D O I：
10.1016/j.fitote.2016.08.008
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This article discusses the mechanisms via topically applied products containing herbs and their active constituents affect the hair growth process. It was reported that the mechanisms involving (1) insulin-like growth factor -I (IGF-I), (2) vascular endothelial growth factor (VEGF), (3) epidermal growth factor (EGF), (4) fibroblast growth factor 2 (FGF-2), (5) endothelial nitric oxide synthase (eNOS), (6) Wnt/beta-catenin signalling pathway, (7) prostaglandin E (PGE), (8) prostaglandin F (PGF) stimulate hair growth, whereas the mechanisms engaging (1) 5 alpha-reductase and dihydrotestosterone (DHT), (2) transforming growth factor beta (TGF-beta), (3) fibroblast growth factor 5 (FGF-5), (4) prostaglandin D-2 (PGD(2)) inhibit hair growth. The knowledge summarized in the paper may be an inspiration to create new preparations for the treatment of hair loss. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：18 / 25
页数：8
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