Potential drug delivery nanosystems for improving tumor penetration

被引：15
|
作者：
Peng, Feifei [1 ]
Li, Ruirui [1 ]
Zhang, Fang [1 ]
Qin, Li [1 ]
Ling, Guixia [1 ]
Zhang, Peng [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, 103 Wenhua Rd, Shenyang 110016, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2020年 / 151卷
基金：
中国国家自然科学基金;
关键词：
Potential; Delivery; Nanosystems; Penetration; Therapies; ENHANCED PHOTODYNAMIC THERAPY; INTERSTITIAL FLUID PRESSURE; RANDOMIZED PHASE-II; DEEP PENETRATION; NANOPARTICLE PENETRATION; SENSITIVE LIPOSOMES; BREAST-CANCER; PHOTOSWITCHABLE NANOPARTICLES; CLUSTERED NANOPARTICLES; EXTRACELLULAR-MATRIX;
D O I：
10.1016/j.ejpb.2020.04.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nanosystems, as one of the most important drug delivery systems, play a crucial rule in tumor therapy. However, the deep tumor penetration is retarded by the tumor physiological factors and nanomedicine properties. In this review, we firstly elaborate the factors which impact tumor penetration, including the tumor physiological factors and nanomedicine properties. Then, the latest and potential drug delivery nanosystems for improving tumor penetration are summarized and analyzed in detail. Moreover, recent combination therapies for improving penetration are described to enhance penetration. Finally, we summarize the typical clinical therapies of potential drug delivery nanosystems.
引用
收藏
页码：220 / 238
页数：19
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