Genetic epidemiology of prostate cancer

被引：25
|
作者：
Narod, S [1 ]
机构：
[1] Womens Coll Hosp, Dept Med, Toronto, ON M5G 1N8, Canada
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 1999年 / 1423卷 / 01期
关键词：
prostate cancer; genetics; hereditary; HPC1; familial; linkage analysis;
D O I：
10.1016/S0304-419X(98)00030-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A family history of prostate cancer is a consistent risk factor for prostate cancer, and can also be used to predict the presence of prostate cancer among asymptomatic men who undergo PSA screening. Approximately 5% of cases of prostate cancer have a familial component. The genetic epidemiology of prostate cancer is complex, and genes on chromosome 1 and X chromosome contribute to familial aggregation. Neither of these prostate cancer susceptibility genes have been identified, but are the subject of an active search. Hereditary prostate cancer resembles non-hereditary prostate cancer in terms of age of onset, pathologic appearance and grade. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：F1 / F13
页数：13
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