Predictors of humoral response to recommended vaccines in HIV-infected adults

被引：6
|
作者：
Tsachouridou, Olga [1 ]
Christaki, Eirini [1 ]
Skoura, Lemonia [2 ]
Georgiou, Adamantini [1 ]
Nanoudis, Sideris [1 ]
Vasdeki, Dimitra [1 ]
Ntziovara, Maria-Anna [1 ]
Kotoreni, Georgia [1 ]
Forozidou, Evropi [1 ]
Tsoukra, Paraskevi [1 ]
Germanidis, Georgios [1 ]
Metallidis, Symeon [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Med Sch, AHEPA Univ Hosp, Dept Internal Med 1, 1 Kiriakidi St, Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, Med Sch, AHEPA Univ Hosp, Microbiol Dept, Thessaloniki, Greece
来源：
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2017年 / 54卷
关键词：
Vaccines; HIV infection; Humoral response; Hepatitis B; Hepatitis A; HEPATITIS-B VACCINATION; ACTIVE ANTIRETROVIRAL THERAPY; A VACCINE; POLYSACCHARIDE VACCINATION; PNEUMOCOCCAL VACCINE; IMMUNE-RESPONSE; IMMUNIZATION; CELLS; IMMUNOGENICITY; ANTIBODY;
D O I：
10.1016/j.cimid.2017.07.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Humoral response to vaccination has been found to be inadequate in individuals infected with the human immunodeficiency virus (HIV). We retrospectively assessed antibody responses to three routinely recommended vaccines, against hepatitis B, hepatitis A and S. pneumoniae, in HIV-infected individuals. Data regarding age at HIV diagnosis, years of infection, sex, nationality, HIV mode of transmission, CD4 cell count, nadir CD4 count, plasma viral load, HIV stage, insurance status, educational level and treatment with Highly Active Antiretroviral Therapy (HAART) were collected. Univariate and multivariate analysis was performed in order to detect factors associated with response to vaccination. 437 patients were assessed for hepatitis B, 627 patients for hepatitis A and 66 patients for S. pneumoniae serologic vaccine responsiveness. Regarding hepatitis B and hepatitis A, education level and insurance status were the only predictors of response. As for S. pneumoniae vaccination HAART and control of viremia were correlated with better response to vaccination.
引用
收藏
页码：27 / 33
页数：7
相关论文
共 50 条
  • [1] Humoral response to influenza vaccination in HIV-infected patients
    Brydak, LB
    Hryniewicz, HJ
    Machala, M
    Horban, A
    CLINICAL DRUG INVESTIGATION, 1999, 17 (06) : 441 - 449
  • [2] ANTIRETROVIRAL THERAPY IN HIV-INFECTED ADULTS - WHICH REGIMENS ARE RECOMMENDED
    LANCASTER, DJ
    LANCASTER, LL
    POSTGRADUATE MEDICINE, 1994, 95 (01) : 47 - &
  • [3] Humoral Response to Influenza Vaccination in HIV-Infected Patients
    Lidia B. Brydak
    Henryk Jan Hryniewicz
    Magdalena Machala
    Andrzej Horban
    Clinical Drug Investigation, 1999, 17 : 441 - 449
  • [4] Safety of live, attenuated oral vaccines in HIV-infected Zambian adults Oral vaccines in HIV
    Banda, Rose
    Yambayamba, Vera
    Lalusha, Bwalya Daka
    Sinkala, Edford
    Kapulu, Melissa Chola
    Kelly, Paul
    VACCINE, 2012, 30 (38) : 5656 - 5660
  • [5] Dysregulated Humoral Immunity to Nontyphoidal Salmonella in HIV-Infected African Adults
    MacLennan, Calman A.
    Gilchrist, James J.
    Gordon, Melita A.
    Cunningham, Adam F.
    Cobbold, Mark
    Goodall, Margaret
    Kingsley, Robert A.
    van Oosterhout, Joep J. G.
    Msefula, Chisomo L.
    Mandala, Wilson L.
    Leyton, Denisse L.
    Marshall, Jennifer L.
    Gondwe, Esther N.
    Bobat, Saeeda
    Lopez-Macias, Constantino
    Doffinger, Rainer
    Henderson, Ian R.
    Zijlstra, Eduard E.
    Dougan, Gordon
    Drayson, Mark T.
    MacLennan, Ian C. M.
    Molyneux, Malcolm E.
    SCIENCE, 2010, 328 (5977) : 508 - 512
  • [6] Prevalence and Predictors of Hypovitaminosis D in Ethiopian HIV-Infected Adults
    Belete, Abebe Muche
    Tefera, Alemu Adela
    Getnet, Mekasha
    Asefa, Adisu
    Aynalem, Yared Asmare
    Shiferaw, Wondimeneh Shibabaw
    HIV AIDS-RESEARCH AND PALLIATIVE CARE, 2021, 13 : 1101 - 1109
  • [7] Clinical predictors for the aetiology of peripheral lymphadenopathy in HIV-infected adults
    Bogoch, I. I.
    Andrews, J. R.
    Nagami, E. H.
    Rivera, A. M.
    Gandhi, R. T.
    Stone, D.
    HIV MEDICINE, 2013, 14 (03) : 182 - 186
  • [8] Humoral immune response following the inactivated quadrivalent influenza vaccination among HIV-infected and HIV-uninfected adults
    Liu, Zhaozhen
    Pang, Can
    Deng, Yuchuan
    Guo, Caiping
    Li, Jia
    Li, Yanping
    Xin, Ruolei
    Li, Xiyao
    Xu, Conghui
    Huang, Chun
    Lu, Hongyan
    Li, Jie
    VACCINE, 2023, 41 (34) : 4978 - 4985
  • [9] Clinical safety of HIV lipopeptides used as vaccines in healthy volunteers and HIV-infected adults
    Durier, C
    Launay, O
    Meiffrédy, V
    Saïdi, Y
    Salmon, D
    Lévy, Y
    Guillet, JG
    Pialoux, G
    Aboulker, JP
    AIDS, 2006, 20 (07) : 1039 - 1049
  • [10] MEASLES SEROPREVALENCE AND VACCINE RESPONSE IN HIV-INFECTED ADULTS
    WALLACE, MR
    HOOPER, DG
    GRAVES, SJ
    MALONE, JL
    VACCINE, 1994, 12 (13) : 1222 - 1224
12345