BLOCKING 17B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 IN ENDOMETRIAL CANCER: A POTENTIAL NOVEL ENDOCRINE THERAPEUTIC APPROACH

被引：0
|
作者：
Cornel, K. M. C. [1 ,2 ]
Konings, G. [2 ,3 ]
Xanthoulea, S. [2 ,3 ]
Delvoux, B. [3 ]
Skowron, M. A. [4 ]
Kooreman, L. [1 ,5 ]
Koskimies, P. [6 ]
Krakstad, C. [7 ,8 ]
Salvesen, H. B. [7 ,8 ]
van Kuijk, K. [1 ,2 ]
Schrooders, Y. J. [1 ,2 ]
Vooijs, M. [1 ,9 ]
Groot, A. J. [1 ,9 ]
Bongers, M. Y. [1 ,2 ]
Kruitwagen, R. R. [1 ,2 ]
Romano, A. [1 ,2 ]
机构：
[1] Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands
[2] Maastricht Univ, Med Ctr, Gynaecol & Obstet, Maastricht, Netherlands
[3] Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands
[4] Heinrich Heine Univ Dusseldorf, Urol, Dusseldorf, Germany
[5] Maastricht Univ, Med Ctr, Pathol, Maastricht, Netherlands
[6] Forendo Pharma Ltd, Turku, Finland
[7] Haukeland Hosp, Gynaecol & Obstet, Bergen, Norway
[8] Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers, Bergen, Norway
[9] Maastricht Univ, Dept Radiotherapy MAASTRO, Maastricht, Netherlands
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 2019年 / 29卷
关键词：
D O I：
10.1136/ijgc-2019-ESGO.560
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
EP502
引用
收藏
页码：A312 / A313
页数：2
相关论文
共 50 条
  • [1] Blocking 17β-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach
    Konings, Gonda F. J.
    Cornel, Karlijn M. C.
    Xanthoulea, Sofia
    Delvoux, Bert
    Skowron, Margaretha A.
    Kooreman, Loes
    Koskimies, Pasi
    Krakstad, Camilla
    Salvesen, Helga B.
    van Kuijk, Kim
    Schrooders, Yannick J. M.
    Vooijs, Marc
    Groot, Arjan J.
    Bongers, Marlies Y.
    Kruitwagen, Roy F. P. M.
    Romano, Andrea
    JOURNAL OF PATHOLOGY, 2018, 244 (02): : 203 - 214
  • [2] 17B-hydroxysteroid dehydrogenase expression in response to progesterone in endometrial biopsy & Ishikawa cell culture.
    Thung, SF
    Lin, ZH
    Chen, YH
    Utsunomiya, H
    Yin, P
    Bulun, SE
    JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 2006, 13 (02) : 262A - 262A
  • [3] Overexpression of 17β-Hydroxysteroid Dehydrogenase Type 1 Increases the Exposure of Endometrial Cancer to 17β-Estradiol
    Cornel, Karlijn M. C.
    Kruitwagen, Roy F. P. M.
    Delvoux, Bert
    Visconti, Laura
    Van de Vijver, Koen K.
    Day, Joanna M.
    Van Gorp, Toon
    Hermans, Rob J. J.
    Dunselman, Gerard A.
    Romano, Andrea
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (04): : E591 - E601
  • [4] Polymorphisms in genes hydroxysteroid-dehydrogenase-17b type 2 and type 4 and endometrial cancer risk
    Karageorgi, Stalo
    McGrath, Monica
    Lee, I-Min
    Buring, Julie
    Kraft, Peter
    De Vivo, Immaculata
    GYNECOLOGIC ONCOLOGY, 2011, 121 (01) : 54 - 58
  • [5] Preclinical Assessment of 17β-Hydroxysteroid Dehydrogenase-1 in Endometrial Cancer
    Konings, G. F. J.
    Cornel, K. M. C.
    Xanthoulea, S.
    Delvoux, B.
    Saarinen, N.
    Kooreman, L.
    Koskimies, P.
    Krakstad, C.
    Fasmer, K. E.
    Haldorsen, I. S.
    Hakkinen, M. R.
    Auriola, S.
    Dubois, L.
    Lieuwes, N.
    Verhaegen, F.
    Schyns, L. E. J.
    Salvesen, H. B.
    Groot, A. J.
    Bongers, M. Y.
    Kruitwagen, R. F. P.
    Romano, A.
    JOURNAL OF PATHOLOGY, 2018, 246 : S18 - S18
  • [6] Discovery of a bifunctional Type 5 17b-hydroxysteroid dehydrogenase (AKR1C3) inhibitor and androgen receptor antagonist
    Adeniji, Adegoke O.
    Twenter, Barry M.
    Winkler, Jeffrey D.
    Penning, Trevor M.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [7] Novel and potent 17β-hydroxysteroid dehydrogenase type 1 inhibitors
    Lawrence, HR
    Vicker, N
    Allan, GM
    Smith, A
    Mahon, MF
    Tutill, HJ
    Purohit, A
    Reed, MJ
    Potter, BVL
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (08) : 2759 - 2762
  • [8] Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer
    Harada, Koichiro
    Kubo, Hideki
    Tomigahara, Yoshitaka
    Nishioka, Kazuhiko
    Takahashi, Junya
    Momose, Mio
    Inoue, Shinichi
    Kojima, Atsuyuki
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (01) : 272 - 275
  • [9] A Turkish Family with 46,XY Disorder of Sex Development Due to 17b-Hydroxysteroid Dehydrogenase Type 3 Deficiency
    Gurbuz, Fatih
    Turan, Ihsan
    Tastan, Mehmet
    Yuksel, Bilgin
    HORMONE RESEARCH IN PAEDIATRICS, 2018, 90 : 582 - 582
  • [10] High mRNA levels of 17β-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer
    Cornel, Karlijn M. C.
    Krakstad, Camilla
    Delvoux, Bert
    Xanthoulea, Sofia
    Jori, Balazs
    Bongers, Marlies Y.
    Konings, Gonda F. J.
    Kooreman, Loes F. S.
    Kruitwagen, Roy F. P. M.
    Salvesen, Helga B.
    Romano, Andrea
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2017, 442 (0C) : 51 - 57
12345