Biosynthesis and Total Synthesis Studies on the Jadomycin Family of Natural Products

被引：29
|
作者：
Sharif, Ehesan U. [1 ]
O'Doherty, George A. [1 ]
机构：
[1] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 11期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
Natural products; Total synthesis; Biosynthesis; Carbohydrates; Carbasugars; Structure-activity relationships; Jadomycin; Digitoxose; STREPTOMYCES-VENEZUELAE ISP5230; DE-NOVO SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; ITERATIVE DIHYDROXYLATION; B PRODUCTION; ASYMMETRIC AMINOHYDROXYLATION; PHENANTHROVIRIDIN AGLYCON; 2,6-DIDEOXY SUGARS; UNCOMMON SUGARS; GENE-CLUSTER;
D O I：
10.1002/ejoc.201101609
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Jadomycins are unique angucycline polyketides produced by Streptomyces venezuelae soil bacteria under specific nutrient and environmental conditions. Their unique structural complexity and biological activities have engendered extensive study of the jadomycin class of natural compounds in terms of biological activity, biosynthesis, and synthesis. This review outlines recent developments in the study of the synthesis and biosynthesis of jadomycins.
引用
收藏
页码：2095 / 2108
页数：14
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