Chitosan-based hydrogels have been widely used in biomedical applications owing to their versatile properties. A novel chitosan-poly (ethylene glycol)-hydrocaffeic acid (CS-PEG-HA) hybrid hydrogel was fabricated, with a four-fold improvement in the mechanical performance as compared to the pure chitosan hydrogel, while enhancing the mucoadhesiveness and hemostasis properties. The in vivo studies on the CS-PEG-HA hydrogel demonstrated that liver bleeding could be rapidly repaired because of the outstanding adhesion and hemostasis characteristics of the developed hydrogel. Additionally, the in vivo wound healing efficacy studies indicated that the CS-PEG-HA hydrogel significantly accelerated the healing rate in a full-thickness skin defect model, thereby helping to successfully reconstruct an intact and thickened epidermis in 14 days. Overall, the developed multifunctional hybrid hydrogel provides a novel method for in vivo visceral hemostasis and accelerated healing of cutaneous skin wounds.
机构:
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou,510632, ChinaKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou,510632, China
Li, Hang
Zhou, Xujie
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机构:
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou,510632, ChinaKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou,510632, China
Zhou, Xujie
Luo, Lei
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机构:
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou,510632, ChinaKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou,510632, China
Luo, Lei
Ding, Qiang
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机构:
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou,510632, ChinaKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou,510632, China
机构:
Department of Stomatology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University
Zheng-Wei Shao
论文数: 引用数:
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机构:
Yu-Shi He
Jia-Yu Lu
论文数: 0引用数: 0
h-index: 0
机构:
Department of Stomatology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University
Jia-Yu Lu
De-Rong Zou
论文数: 0引用数: 0
h-index: 0
机构:
Department of Stomatology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University
De-Rong Zou
Chuan-Liang Feng
论文数: 0引用数: 0
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机构:
School of Materials Science and Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University
机构:Shanghai Jiao Tong University,School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging
Lin Teng
Zheng-Wei Shao
论文数: 0引用数: 0
h-index: 0
机构:Shanghai Jiao Tong University,School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging
Zheng-Wei Shao
Yu-Shi He
论文数: 0引用数: 0
h-index: 0
机构:Shanghai Jiao Tong University,School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging
Yu-Shi He
Jia-Yu Lu
论文数: 0引用数: 0
h-index: 0
机构:Shanghai Jiao Tong University,School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging
Jia-Yu Lu
De-Rong Zou
论文数: 0引用数: 0
h-index: 0
机构:Shanghai Jiao Tong University,School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging
De-Rong Zou
Chuan-Liang Feng
论文数: 0引用数: 0
h-index: 0
机构:Shanghai Jiao Tong University,School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging
Chuan-Liang Feng
Chang-Ming Dong
论文数: 0引用数: 0
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机构:Shanghai Jiao Tong University,School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging
Chang-Ming Dong
[J].
Chinese Journal of Polymer Science,
2022,
40
: 1110
-
1119
机构:
Stanford Univ, Ophthalmol, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Ophthalmol, Palo Alto, CA USAStanford Univ, Ophthalmol, Stanford, CA 94305 USA
Myung, David
Chen, Fang
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机构:
Stanford Univ, Ophthalmol, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Ophthalmol, Palo Alto, CA USAStanford Univ, Ophthalmol, Stanford, CA 94305 USA
Chen, Fang
Fernandes-Cunha, Gabriella
论文数: 0引用数: 0
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机构:
Stanford Univ, Ophthalmol, Stanford, CA 94305 USAStanford Univ, Ophthalmol, Stanford, CA 94305 USA
Fernandes-Cunha, Gabriella
Le, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Ophthalmol, Stanford, CA 94305 USAStanford Univ, Ophthalmol, Stanford, CA 94305 USA
Le, Peter
Hull, Sarah
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Chem Engn, Stanford, CA 94305 USAStanford Univ, Ophthalmol, Stanford, CA 94305 USA
Hull, Sarah
Heilshorn, Sarah
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Mat Sci & Engn, Stanford, CA 94305 USAStanford Univ, Ophthalmol, Stanford, CA 94305 USA
机构:
Stanford Univ, Sch Med, Ophthalmol, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Palo Alto, CA USAStanford Univ, Sch Med, Ophthalmol, Stanford, CA 94305 USA
Chen, Fang
Le, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Ophthalmol, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Palo Alto, CA USAStanford Univ, Sch Med, Ophthalmol, Stanford, CA 94305 USA
Le, Peter
Fernandes-Cunha, Gabriella M.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Ophthalmol, Stanford, CA 94305 USAStanford Univ, Sch Med, Ophthalmol, Stanford, CA 94305 USA
Fernandes-Cunha, Gabriella M.
Heilshorn, Sarah C.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Mat Sci & Engn, Stanford, CA 94305 USAStanford Univ, Sch Med, Ophthalmol, Stanford, CA 94305 USA
Heilshorn, Sarah C.
Myung, David
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Ophthalmol, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Palo Alto, CA USA
Stanford Univ, Chem Engn, Stanford, CA 94305 USAStanford Univ, Sch Med, Ophthalmol, Stanford, CA 94305 USA
机构:
Stanford Univ, Sch Med, Byers Eye Inst, Palo Alto, CA 94303 USAStanford Univ, Sch Med, Byers Eye Inst, Palo Alto, CA 94303 USA
Lee, Hyun Jong
Fernandes-Cunha, Gabriella M.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Byers Eye Inst, Palo Alto, CA 94303 USAStanford Univ, Sch Med, Byers Eye Inst, Palo Alto, CA 94303 USA
Fernandes-Cunha, Gabriella M.
论文数: 引用数:
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Na, Kyung-Sun
Hull, Sarah M.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USAStanford Univ, Sch Med, Byers Eye Inst, Palo Alto, CA 94303 USA
Hull, Sarah M.
Myung, David
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Byers Eye Inst, Palo Alto, CA 94303 USA
VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USAStanford Univ, Sch Med, Byers Eye Inst, Palo Alto, CA 94303 USA
机构:
Wuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R ChinaWuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
Yang, Erkang
Hou, Wen
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R ChinaWuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
Hou, Wen
Liu, Kun
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机构:
Wuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R ChinaWuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
Liu, Kun
Yang, He
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R ChinaWuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
Yang, He
Wei, Wenying
论文数: 0引用数: 0
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机构:
Wuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R ChinaWuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
Wei, Wenying
Kang, Haifei
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机构:
Wuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R ChinaWuhan Univ Technol, Biomed Mat & Engn Res Ctr Hubei Prov, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China