The past, present, and future of enzyme-based therapies

被引：17

作者：

Hennigan, Jennifer N. ^{[1
]}

Lynch, Michael D. ^{[2
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27706 USA

[2] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA

来源：

DRUG DISCOVERY TODAY | 2022年 / 27卷 / 01期

关键词：

Enzyme based therapy; Enzyme; Therapy; Biologic; Therapeutic enzymes; Clinical; Pre-clinical; Early investigational; Biotechnology; History; COLLAGENASE CLOSTRIDIUM-HISTOLYTICUM; RECOMBINANT HUMAN HYALURONIDASE; PHENYLALANINE AMMONIA-LYASE; HUMAN PLASMA FRACTIONATION; HUMAN SUPEROXIDE-DISMUTASE; PRODRUG THERAPY; DOUBLE-BLIND; BOTULINUM NEUROTOXIN; L-ASPARAGINASE; CANCER;

D O I：

10.1016/j.drudis.2021.09.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Enzyme-based therapeutics (EBTs) have the potential to tap into an almost unmeasurable amount of enzyme biodiversity and treat myriad conditions. Although EBTs were some of the first biologics used clinically, the rate of development of newer EBTs has lagged behind that of other biologics. Here, we review the history of EBTs, and discuss the state of each class of EBT, their potential clinical advantages, and the unique challenges to their development. Additionally, we discuss key remaining technical barriers that, if addressed, could increase the diversity and rate of the development of EBTs.

引用

页码：117 / 133

页数：17

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