Functional vascular endothelial growth factor gene polymorphisms and diabetes: Effect on coronary collaterals in patients with significant coronary artery disease

Background Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis This study tested the association between functional VEGF +405 C>G (rs2010963). -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD) Method The collateral scoring system developed by Rentrop was used to classify 393 patients according to their collaterals as either "poor" (grades 0 and 1) or "good" (grades 2 and 3) Gene polymorphisms were analyzed by TaqMan assay Results The frequency of +405C and -2578A alleles was higher in the good collaterals group (p=0 007 and 0005. respectively) For the +405C>G allele, the odds ratio (OR) of good collaterals for CC to GG genotype was 254 (p=0 003) For the -2578A allele, the OR of good collaterals for AA to CC genotype was 231 (p=0 038) Univariate and logistic regression analysis found 2 polymorphisms in the additive model for associations with collateral development: +405C>G (p = 0 005 and 0 010) and -2578C>A (p = 0.006 and 0006). The VEGF +405C>G polymorphism and DM revealed an interactive effect on collateral development (p = 0 027) Conclusions The VEGF +405C>G and -2578C>A polymorphisms might be novel genetic factors affecting collateral development in Chinese patients. (C) 2010 Elsevier BV All rights reserved