Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak

被引：7

作者：

Keita, Alpha K. ^{[1
,2
,3
]}

Butel, Christelle ^{[1
]}

Thaurignac, Guillaume ^{[1
]}

Diallo, Aminata ^{[4
]}

Nioke, Talla ^{[4
]}

Traore, Falaye ^{[4
]}

Koivogui, Lamine ^{[4
]}

Peeters, Martine ^{[1
]}

Delaporte, Eric ^{[1
]}

Ayouba, Ahidjo ^{[1
]}

机构：

[1] Montpellier Univ, IRD, UMI 23, INSERM,U1175, 911 Ave Agropolis,BP 64501, F-34394 Montpellier 5, France

[2] Inst Natl Sante Publ, OneHlth Lab, Conakry, Guinea

[3] Ctr Rech & Format Infectiol Guinee CERFIG, Conakry, Guinea

[4] Inst Natl Sante Publ, Conakry, Guinea

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2018年 / 99卷 / 02期

关键词：

ANTIBODIES; ASSAY;

D O I：

10.4269/ajtmh.18-0105

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Questions remain as to whether an unnoticed Ebola outbreak occurred in Guinea before the 2014-2016 epidemic. To address this, we used a highly sensitive and specific Luminex-based assay for Ebola virus (EBOV) antibody detection to screen blood samples collected in the framework of the Demographic Health Survey performed in 2012 in Guinea. One sample (GF069) of 1,483 tested was positive at very high immunoglobulin G titer to Zaire EBOV in Guinee Forestiere. Thus, at least 2 years before the 2014 EVD outbreak in Guinea, Zaire EBOV was circulating in rural areas of this country.

引用

页码：425 / 427

页数：3

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