NFAT, immunity and cancer: a transcription factor comes of age

被引：457
|
作者：
Mueller, Martin R. [1 ]
Rao, Anjana [2 ,3 ,4 ]
机构：
[1] Univ Tubingen, Dept Haematol Oncol & Immunol, Med Klin & Poliklin, D-72076 Tubingen, Germany
[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[3] Childrens Hosp Boston, Immune Dis Inst, Program Cellular & Mol Med, Boston, MA 02115 USA
[4] La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 09期
基金：
美国国家卫生研究院;
关键词：
REGULATORY T-CELLS; NUCLEAR-FACTOR; CYCLOSPORINE-A; KAPPA-B; FOXP3; EXPRESSION; GENE-EXPRESSION; MAST-CELLS; SELECTIVE-INHIBITION; SIGNALING PROTEINS; ANTIGEN RECEPTOR;
D O I：
10.1038/nri2818
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It is now clear that NFAT proteins have important functions in other cells of the immune system and regulate numerous developmental programmes in vertebrates. Dysregulation of these programmes can lead to malignant growth and cancer. This Review focuses on recent advances in our understanding of the transcriptional functions of NFAT proteins in the immune system and provides new insights into their potential roles in cancer development.
引用
收藏
页码：645 / 656
页数：12
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