Role of Vascular Extracellular Superoxide Dismutase in Hypertension

被引:44
|
作者
Lob, Heinrich E. [3 ]
Vinh, Antony [3 ]
Li, Li [3 ]
Blinder, Yelena [3 ]
Offermanns, Stefan [4 ]
Harrison, David G. [1 ,2 ,3 ]
机构
[1] Vanderbilt Univ, Div Clin Pharmacol, Sch Med, Dept Internal Med, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Div Cardiol, Dept Internal Med, Nashville, TN 37232 USA
[3] Emory Univ, Sch Med, Div Cardiol, Dept Med, Atlanta, GA 30322 USA
[4] Max Planck Inst Heart & Lung Res, Bad Nauheim, Germany
基金
美国国家卫生研究院;
关键词
superoxide dismutase; blood pressure; inflammation; vasculature; central nervous system; II-INDUCED HYPERTENSION; CENTRAL-NERVOUS-SYSTEM; ANGIOTENSIN-II; SMOOTH-MUSCLE; BLOOD-PRESSURE; NITRIC-OXIDE; THIOL/DISULFIDE REDOX; OXIDATIVE STRESS; RELAXING FACTOR; OBESE MICE;
D O I
10.1161/HYPERTENSIONAHA.111.172718
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Previous studies indicate that superoxide is important in the modulation of blood pressure but have not specifically identified the cell types or organs involved. We created mice with loxP sites flanking the extracellular superoxide dismutase (SOD3) gene. These mice were crossed with mice expressing inducible Cre-recombinase driven by the smooth muscle myosin heavy chain promoter allowing tissue-specific deletion of SOD3. Deletion of SOD3 increased vascular superoxide and reduced vascular NO levels as detected by electron spin resonance. Despite these changes in NO and superoxide, we did not observe increases in vascular inflammation caused by angiotensin II. Moreover, deletion of vascular SOD3 did not augment hypertension in response to angiotensin II. In additional studies, we also deleted SOD3 from the circumventricular organs by intracerebroventricular injection of an adenovirus encoding Cre-recombinase. Although this raised blood pressure and augmented the hypertension caused by angiotensin II, these responses were not further increased by vascular deletion of SOD3. These data suggest that the extracellular superoxide dismutase in vascular smooth muscle is not involved in the genesis of angiotensin II-induced hypertension and further emphasize the role of central SOD3 in the modulation of blood pressure. (Hypertension. 2011;58:232-239.)
引用
收藏
页码:232 / U213
页数:11
相关论文
共 50 条
  • [1] Role of extracellular superoxide dismutase in hypertension
    Gongora, Maria Carolina
    Qin, Zhenyu
    Laude, Karine
    Kim, Ha Won
    McCann, Louise
    Folz, J. Rodney
    Dikalov, Sergey
    Fukai, Tohru
    Harrison, David G.
    [J]. HYPERTENSION, 2006, 48 (03) : 473 - 481
  • [2] Angiotensin II, hypertension and the vascular extracellular superoxide dismutase
    Fukai, T
    Siegfried, MR
    Ushio-Fukai, M
    Harrison, DG
    [J]. CIRCULATION, 1998, 98 (17) : 310 - 311
  • [3] The role of extracellular superoxide dismutase in angiotensin II-induced hypertension
    Fukai, T
    Folz, RJ
    McCann, L
    Cheng, Y
    Landmesser, U
    Harrison, DG
    [J]. CIRCULATION, 2000, 102 (18) : 302 - 302
  • [4] Vascular expression of extracellular superoxide dismutase in atherosclerosis
    Fukai, T
    Galis, ZS
    Meng, XP
    Parthasarathy, S
    Harrison, DG
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (10): : 2101 - 2111
  • [5] Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension
    Victor Tseng
    Kevin Ni
    Ayed Allawzi
    Clare Prohaska
    Laura Hernandez-Lagunas
    Hanan Elajaili
    Valbona Cali
    Ronald Midura
    Vincent Hascall
    Barbara Triggs-Raine
    Irina Petrache
    C. Michael Hart
    Eva Nozik-Grayck
    [J]. Scientific Reports, 10
  • [6] Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension
    Tseng, Victor
    Ni, Kevin
    Allawzi, Ayed
    Prohaska, Clare
    Hernandez-Lagunas, Laura
    Elajaili, Hanan
    Cali, Valbona
    Midura, Ronald
    Hascall, Vincent
    Triggs-Raine, Barbara
    Petrache, Irina
    Hart, C. Michael
    Nozik-Grayck, Eva
    [J]. SCIENTIFIC REPORTS, 2020, 10 (01)
  • [7] PHARMACOKINETICS OF EXTRACELLULAR-SUPEROXIDE DISMUTASE IN THE VASCULAR SYSTEM
    KARLSSON, K
    SANDSTROM, J
    EDLUND, A
    EDLUND, T
    MARKLUND, SL
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1993, 14 (02) : 185 - 190
  • [8] EXTRACELLULAR SUPEROXIDE-DISMUTASE IN THE VASCULAR SYSTEM OF MAMMALS
    KARLSSON, K
    MARKLUND, SL
    [J]. BIOCHEMICAL JOURNAL, 1988, 255 (01) : 223 - 228
  • [9] Extracellular superoxide dismutase and its role in cancer
    Griess, Brandon
    Tom, Eric
    Domann, Frederick
    Teoh-Fitzgerald, Melissa
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2017, 112 : 464 - 479
  • [10] The Role of Extracellular Superoxide Dismutase in Bacterial Pneumonia
    Manni, Michelle L.
    Tomai, Lauren P.
    Norris, Callie A.
    Thomas, L. Michael
    Salter, Russell D.
    Oury, Tim D.
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2009, 47 : S146 - S146