Composition of polysaccharides from Alectryon tomentosus F. Muell. leaves with potential cytotoxic and antimicrobial activities

被引：2

作者：

Aboutabl, Elsayed Ali ^{[1
]}

Elsawi, Salma Ahmed ^{[2
]}

Rashed, Khaled Nabih ^{[2
]}

Ragab, Nermin Ahmed ^{[2
]}

机构：

[1] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt

[2] Natl Res Ctr, Dept Pharmacognosy, Cairo, Egypt

来源：

STARCH-STARKE | 2016年 / 68卷 / 9-10期

关键词：

Alectryon tomentosus; Antimicrobial activity; Cytotoxic activity; Polysaccharides; ANTITUMOR-ACTIVITY; CANCER;

D O I：

10.1002/star.201500317

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Cold and hot water soluble polysaccharides (CWP and HWP) of Alectryon tomentosus were obtained from defatted powdered leaves samples, pre-extracted with 80% ethanol. The CWP and HWP were subjected to hydrolysis and silylation followed by gas liquid chromatography (GLC) to establish its monosaccharide composition. They were found to be rich in rhamnose, galactose, and arabinose by 16.99, 19.03, and 9.71% versus 30.06, 13.14, and 8.07% for CWP and HWP, respectively. The CWP and HWP were evaluated for their cytotoxic and antimicrobial activity using SulphoRhodamine-B (SRB) cell survival assay and agar well diffusion method, respectively. The HWP showed significant cytotoxic activities against breast cancer cells (MCF-7) and liver cancer cells (HepG2) at IC50=3.83 and 12.20g/dL, respectively, whereas the CWP showed an appreciable cytotoxic activity against colon cancer cells (HCT 116) at IC50=23.92g/dL. CWP exhibited a significant antimicrobial activity against Bacillus subtilis (Gram-positive bacteria).

引用

页码：929 / 934

页数：6

共 50 条

[1] Phenolic Compounds from the Leaves of Eucalyptus microcorys F. Muell.
Fortes, Gilmara A. C.
da Silva, Antonio J. R.
Ferri, Pedro H.
Santos, Suzana C.
RECORDS OF NATURAL PRODUCTS, 2015, 9 (03) : 292 - 296
[2] Essential oils from the leaves of Bosistoa F. Muell. ex Benth. (Rutaceae)
Brophy, Joseph J.
Goldsack, Robert J.
Forster, Paul I.
JOURNAL OF ESSENTIAL OIL RESEARCH, 2007, 19 (03) : 249 - 254
[3] Cytotoxic activity of acyl phloroglucinols isolated from the leaves of Eucalyptus cinerea F. Muell. ex Benth. cultivated in Egypt
Fathy M. Soliman
Magda M. Fathy
Maha M. Salama
Ahmed M. Al-Abd
Fatema R. Saber
Ali M. El-Halawany
Scientific Reports, 4
[4] Cytotoxic activity of acyl phloroglucinols isolated from the leaves of Eucalyptus cinerea F. Muell. ex Benth. cultivated in Egypt
Soliman, Fathy M.
Fathy, Magda M.
Salama, Maha M.
Al-Abd, Ahmed M.
Saber, Fatema R.
El-Halawany, Ali M.
SCIENTIFIC REPORTS, 2014, 4
[5] Potent antimicrobial compounds from the Australian medicinal plant Eremophila duttonii (F. Muell.) (Myoporaceae)
Jones, G.
Smith, J.
Watson, K.
Tucker, D.
PLANTA MEDICA, 2007, 73 (09) : 952 - 952
[6] Bioactive compounds from the bark of Eucalyptus exserta F. Muell.
Li, Jingjing
Xu, Hanhong
INDUSTRIAL CROPS AND PRODUCTS, 2012, 40 : 302 - 306
[7] Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves
Fagundes, Leopoldina Leonor
Vieira, Glauciemar Del-Vechio
de Pinho, Jose de Jesus R. G.
Yamamoto, Celia Hitomi
Alves, Maria Silvana
Stringheta, Paulo Cesar
de Sousa, Orlando Vieira
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2010, 11 (10) : 3942 - 3953
[8] Plant regeneration from mesophyll protoplasts of Goodenia scaevolina F. Muell.
Sugimoto, K
Lidbetter, J
JOURNAL OF THE JAPANESE SOCIETY FOR HORTICULTURAL SCIENCE, 2003, 72 (04): : 281 - 285
[9] Bioactivity of ethanol extracts from Eucalyptus bosistoana F. Muell. heartwood
Mishra, Gayatri
Garrill, Ashley
Altaner, Clemens M.
IFOREST-BIOGEOSCIENCES AND FORESTRY, 2019, 12 : 467 - 473
[10] Extraction of Essential Oil from River Tea Tree (Melaleuca bracteata F. Muell.): Antioxidant and Antimicrobial Properties
Yasin, Mursleen
Younis, Adnan
Ramzan, Fahad
Javed, Talha
Shabbir, Rubab
Noushahi, Hamza Armghan
Skalicky, Milan
Ondrisik, Peter
Brestic, Marian
Hassan, Sabry
EL Sabagh, Ayman
SUSTAINABILITY, 2021, 13 (09)

← 1 2 3 4 5 →