Titanium Dioxide Nanoparticles Induce Oxidative Stress-Mediated Apoptosis in Human Keratinocyte Cells

被引：88
|
作者：
Shukla, Ritesh K. [1 ]
Kumar, Ashutosh [1 ]
Pandey, Alok K. [1 ]
Singh, Shashi S. [2 ]
Dhawan, Alok [1 ]
机构：
[1] Indian Inst Toxicol Res CSIR, Nanomat Toxicol Grp, Lucknow 226001, Uttar Pradesh, India
[2] Ctr Cellular & Mol Biol CSIR, Hyderabad 500007, Andhra Pradesh, India
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2011年 / 7卷 / 01期
关键词：
TiO(2) Nanoparticles; Human Keratinocyte Cells; Skin; ASSAY;
D O I：
10.1166/jbn.2011.1221
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Titanium dioxide nanoparticles (TiO(2) NPs) are the most commonly used metal oxide NPs in various industrial and commercial products. The present study has demonstrated a significant cellular uptake of TiO(2) NPs in the human keratinocyte cells (HaCaT) using transmission electron microscopy and flow cytometry. The data exhibited a significant (p < 0.05) concentration dependent decrease in cell viability and glutathione with concomitant increase in lipid peroxidation and reactive oxygen species. The increased oxidative stress further leads to apoptosis after 48 h of exposure. Our study demonstrates oxidative stress mediated apoptosis in human keratinocyte cells exposed to TiO(2) NPs.
引用
收藏
页码：100 / 101
页数：2
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