Design and synthesis of imidazolo-1, 2,3-triazoles hybrid compounds by microwave-assisted method: Evaluation as an antioxidant and antimicrobial agents and molecular docking studies

The present manuscript describes synthesis of a new class of antimicrobial and antioxidant agents (imidazole linked 1,2,3-triazole hybrid compounds) and screened for their in-vitro studies for antimicrobial and antioxidant activity. In the present investigation, We have developed a simple and convenient method to design and synthesize imidazole linked mono-triazole (6) as well as imidazole linked bistriazole (9) derivatives by using the click reaction followed by multi component reaction for compounds (6) and vice-versa for the synthesis of compounds (9). The reactions were carried out by two different techniques, conventional heating and microwave irradiation. Microwave irradiation method offers excellent yields, lesser reaction times and environmental friendly reactions. These compounds were studied for their antimicrobial, antioxidant and molecular docking studies using Schrodinger suite. For their in-vitro antimicrobial activity against gram-positive, gram-negative strains; preliminary results indicated that some target compounds exhibited promising antimicrobial potency especially 6c, 6h, 9d, 9e and 9h. Further these compounds were tested for their in-vitro antioxidant activity using four different methods few of them are exhibited excellent antioxidant activity especially 6d, 6h, 9a, 9c, 9e, 9f, 9h. In addition these compounds activity relationship were further supported by in-silico molecular docking studies some of the active compounds 6c, 6h, 9d and 9e showed maximum dock score. (C) 2018 Published by Elsevier B.V.