Effects of zinc deficiency and supplementation on plasma leptin levels in rats

被引:26
|
作者
Baltaci, AK [1 ]
Mogulkoc, R
Halifeoglu, I
机构
[1] Selcuk Univ, Meram Med Sch, Dept Physiol, Konya, Turkey
[2] Firat Univ, Sch Med, Dept Biochem, Elazig, Turkey
关键词
zinc deficiency and supplementation; leptin; rat;
D O I
10.1385/BTER:104:1:041
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of zinc deficiency and supplementation on plasma leptin levels were studied in Sprague-Dawley rats. After 6 wk on a zinc-deficient diet containing 0.65 ppm Zn/g, the mean body weight was significantly lower than that of normal or zinc-supplemented rats, which showed no difference among them. The plasma leptin and zinc levels were lowest in zinc-deficient animals and highest in those that received a normal diet and daily intraperitioneal injections of 3 mg Zn/kg. These results indicate that zinc deficiency leads to a significant inhibition in plasma leptin levels, whereas zinc supplementation significantly increases plasma leptin.
引用
收藏
页码:41 / 46
页数:6
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