CD8+ T-cell lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis during methotrexate therapy

被引：12
|
作者：
Hatachi, Saori [1 ]
Kunitomi, Akane [2 ]
Aozasa, Katsuyuki [3 ]
Yagita, Masato [1 ]
机构：
[1] Kitano Hosp, Div Clin Immunol & Rheumatol, Dept Med, Kita Ku, Osaka 5308480, Japan
[2] Japanese Red Cross Soc Wakayama Med Ctr, Dept Hematol, Wakayama 6408558, Japan
[3] Osaka Univ, Grad Sch Med, Dept Pathol, Suita, Osaka 5650871, Japan
来源：
MODERN RHEUMATOLOGY | 2010年 / 20卷 / 05期
关键词：
CD8 T cells; EBV; LPD; MTX; RA; LYMPHOMA; CANCER; SYSTEM; RISK;
D O I：
10.1007/s10165-010-0300-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 75-year-old woman with rheumatoid arthritis (RA) who was receiving methotrexate (MTX) therapy developed Epstein-Barr virus (EBV)-associated CD8(+) T-cell lymphoproliferative disorder (LPD) and meningoencephalitis. She was successfully treated with acyclovir and corticosteroids plus MTX cessation. T-cell LPD is relatively rare in RA patients receiving MTX. To our knowledge, this is the first report of CD8(+) T-cell LPD with EBV genome occurring during MTX therapy for RA. EBV infection should be carefully monitored to assess severe EBV-associated complications.
引用
收藏
页码：500 / 505
页数：6
相关论文
共 50 条
  • [1] CD8-positive T-cell lymphoproliferative disorder associated with Epstein-Barr virus-infected B-cells in a rheumatoid arthritis patient under methotrexate treatment
    Koji, Hitoshi
    Yazawa, Takuya
    Nakabayashi, Kimimasa
    Fujioka, Yasunori
    Kamma, Hiroshi
    Yamada, Akira
    MODERN RHEUMATOLOGY, 2016, 26 (02) : 271 - 275
  • [2] Methotrexate-related Epstein-Barr virus-associated lymphoproliferative disorder occurring in the gingiva of a patient with rheumatoid arthritis
    Ishida, Mitsuaki
    Hodohara, Keiko
    Yoshii, Miyuki
    Okuno, Hiroko
    Horinouchi, Akiko
    Nakanishi, Ryota
    Harada, Ayumi
    Iwai, Muneo
    Yoshida, Keiko
    Kagotani, Akiko
    Yoshida, Takashi
    Okabe, Hidetoshi
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2013, 6 (10): : 2237 - 2241
  • [3] Reversible methotrexate-associated lymphoproliferative disorder (MTX-LPD) associated with Epstein-Barr virus in a patient with rheumatoid arthritis
    Miyashita, Midori
    Koike, Takeshi
    Aizawa, Hitoshi
    Kurita, Hiroshi
    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 2015, 27 (05) : 673 - 676
  • [4] Reversible infliximab-related lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis
    Komatsuda, Atsushi
    Wakui, Hideki
    Nimura, Takashi
    Sawada, Ken-ichi
    MODERN RHEUMATOLOGY, 2008, 18 (03) : 315 - 318
  • [5] Improving T-Cell Therapy for Epstein-Barr Virus Lymphoproliferative Disorders
    Bollard, Catherine M.
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (01) : 5 - 7
  • [6] Epstein-Barr virus-associated T-cell lymphoproliferative disorder affecting skin and lung in an elderly patient
    Hoshino, Tomomi
    Tatsuno, Kazuki
    Shimauchi, Takatoshi
    Okada, Satoko
    Ito, Taisuke
    Ono, Takaaki
    Ohshima, Koichi
    Tokura, Yoshiki
    JOURNAL OF DERMATOLOGY, 2014, 41 (09): : 837 - 840
  • [7] Involvement of Epstein-Barr virus in the development and spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis
    Kitamura, N.
    Sugiyama, K.
    Nagasawa, Y.
    Hamaguchi, M.
    Kobayashi, H.
    Takei, M.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2022, 40 (07) : 1330 - 1335
  • [8] Epstein Barr virus related cutaneous T-cell lymphoma associated with juvenile rheumatoid arthritis and methotrexate therapy
    不详
    JOURNAL OF CUTANEOUS PATHOLOGY, 2006, 33 (01) : 66 - 66
  • [9] Epstein-Barr virus-associated lymphoproliferative disease during methotrexate therapy for psoriasis
    Paul, C
    LeTourneau, A
    Cayuela, JM
    Devidas, A
    Robert, C
    Molinie, V
    Dubertret, L
    ARCHIVES OF DERMATOLOGY, 1997, 133 (07) : 867 - 871
  • [10] Reversal of multifocal cutaneous lymphoproliferative disease associated with Epstein-Barr virus after withdrawal of methotrexate therapy for rheumatoid arthritis
    Maruani, Annabel
    Wierzbicka, Ewa
    Machet, Marie-Christine
    Abdallah-Lotf, Myriam
    De Muret, Anne
    Machet, Laurent
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2007, 57 (05) : S69 - S71
12345