Immune-to-brain communication dynamically modulates pain: Physiological and pathological consequences

被引:99
|
作者
Wieseler-Frank, J
Maier, SF
Watkins, LR
机构
[1] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA
[2] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA
关键词
glia; proinflammatory cytokines; interleukin; 1; 6; tumor necrosis factor; sickness responses; pain facilitation; sciatic inflammatory neuropathy;
D O I
10.1016/j.bbi.2004.08.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This review examines recently recognized roles of immunological processes in pain modulation and explores the potential implications of these immunologically derived phenomena for human chronic pain control. The focus is an examination of how activation of immune-like glial cells within the spinal cord can amplify pain by modulating the excitability of spinal neurons. Such glially driven enhancement of pain can be physiological, as occurs in response to peripheral infection or inflammation. Here, immune-to brain-to-spinal cord communication leads to pain enhancement (hyperalgesia) as one component of the well-characterized sickness response. This sickness-induced hyperalgesia, like many sickness responses, is mediated by the activation of glia and the consequent release of proinflammatory cytokines. However, glially driven pain can also occur under pathological conditions, such as occurs following peripheral nerve inflammation or trauma. Here, immune- and trauma-induced alterations in peripheral nerve function lead to the release of substances within the spinal cord that trigger the activation of glia. Evidence is reviewed that such pathologically driven glial activation is associated with enhanced pain states of diverse etiologies and that such pain facilitation is driven by glial release of proinflammatory cytokines and other neuroexcitatory substances. This recently recognized role of spinal cord glia and glially derived proinflammatory cytokines as powerful modulators of pain is exciting, as it may provide novel approaches for controlling human chronic pain states that are poorly controlled by currently available therapies. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:104 / 111
页数:8
相关论文
共 30 条
  • [1] Implications of immune-to-brain communication for sickness and pain
    Watkins, LR
    Maier, SF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) : 7710 - 7713
  • [2] The pain of being sick: Implications of immune-to-brain communication for understanding pain
    Watkins, LR
    Maier, SF
    [J]. ANNUAL REVIEW OF PSYCHOLOGY, 2000, 51 : 29 - 57
  • [3] Is there a role for immune-to-brain communication in schizophrenia?
    Khandaker, Golam M.
    Dantzer, Robert
    [J]. PSYCHOPHARMACOLOGY, 2016, 233 (09) : 1559 - 1573
  • [4] Is there a role for immune-to-brain communication in schizophrenia?
    Golam M. Khandaker
    Robert Dantzer
    [J]. Psychopharmacology, 2016, 233 : 1559 - 1573
  • [5] Immune-to-brain communication in metabolic disorders and ageing
    Capuron, L.
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2012, 22 : S134 - S134
  • [6] The role of cytokines in immune-to-brain communication following immune stimulation
    Teeling, J. L.
    Lunnon, K. S.
    Cunningham, C.
    Newman, T.
    Perry, V. H.
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2008, 197 (02) : 172 - 173
  • [7] Vagal immune-to-brain communication: a visceral chemosensory pathway
    Goehler, LE
    Gaykema, RPA
    Hansen, MK
    Anderson, K
    Maier, SF
    Watkins, LR
    [J]. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2000, 85 (1-3): : 49 - 59
  • [8] Experimental human endotoxemia: A model to disentangle the immune-to-brain communication
    Schedlowski, Manfred
    Grigoleit, Jan-sebastian
    Engler, Harald
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2014, 275 (1-2) : 185 - 185
  • [9] Immune drivers of physiological and pathological pain
    Jain, Aakanksha
    Hakim, Sara
    Woolf, Clifford J.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2024, 221 (05):
  • [10] The Role of Inflammatory Mediators in Immune-to-Brain Communication during Health and Disease
    Gomez-Nicola, Diego
    Teeling, Jessica
    Guaza, Carmen
    Godbout, Jonathan P.
    Taub, Dennis D.
    [J]. MEDIATORS OF INFLAMMATION, 2013, 2013