Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer

被引：12
|
作者：
Wong, JCY
Gokgoz, N
Alon, N
Andrulis, IL
Buchwald, M
机构：
[1] Hosp Sick Children, Res Inst, Program Genet & Genom Biol, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada
[3] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Fred A Litwin Ctr Canc Genet, Toronto, ON M5G 1X5, Canada
来源：
JOURNAL OF HUMAN GENETICS | 2003年 / 48卷 / 12期
关键词：
zinc finger protein; breast cancer; tumor suppressor; 16q24.3; polymorphism;
D O I：
10.1007/s10038-003-0088-1
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Loss of heterozygosity (LOH) involving chromosome 16q23.4 occurs frequently in breast tumors, which suggests that this region may contain a tumor suppressor gene. Since ZFP276 is located in this region, we have therefore cloned and performed mutation analysis of its coding region in 70 breast tumors. One silent polymorphism and two alterations predicted to result in amino acid changes were detected. Absence of the wild-type allele in tumors carrying the E530D variant suggests a possible role for this change in tumorigenesis.
引用
收藏
页码：668 / 671
页数：4
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