SYNTHESIS AND CALMING ACTIVITY OF 2-AMINO-4-(4-β-D-ALLOPYRANOSIDE-PHENYL)-6-3(4)-SUBSTITUTED PHENYLPYRIMIDINES

被引：3
|
作者：
Yin, XiuJuan [1 ]
Zheng, Lei [1 ]
Li, Ying [1 ]
Yin, ShuFan [1 ]
机构：
[1] Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2010年 / 46卷 / 05期
关键词：
helicid; guanidine hydrochloride; pyrimidine; calming activity; DERIVATIVES; PHASE;
D O I：
10.1007/s10600-010-9739-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Using helicid as starting material, E-4-beta-D-allopyranoside-cinnamic-4-substituted phenylketones (1a-1h) containing the structure of chalcones were synthesized; then these chalcones were reacted with guanidine hydrochloride through a 1,4-Michael reaction, giving 2-amino-4-(4-beta-D-allopyranoside-phenyl)-6- 3(4)-substituted phenylpyrimidines (2a-2h), which were characterized by IR, H-1 NMR, and HR-MS. The target compounds were evaluated by the spontaneous locomotor activity test, showing that all of them had good calming activity; compound 2f was found to have the greatest.
引用
收藏
页码：779 / 782
页数：4
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