A review on injectable chitosan/beta glycerophosphate hydrogels for bone tissue regeneration

被引：159
|
作者：
Saravanan, Sekaran [1 ]
Vimalraj, Selvaraj [2 ]
Thanikaivelan, Palanisamy [3 ]
Banudevi, Sivanantham [1 ]
Manivasagam, Geetha [4 ]
机构：
[1] SASTRA Univ, Sch Chem & Biotechnol, Dept Bioengn, Ctr Nanotechnol & Adv Biomat CeNTAB, Thanjavur 613401, Tamil Nadu, India
[2] Anna Univ, Ctr Biotechnol, Madras 600025, Tamil Nadu, India
[3] CSIR, Cent Leather Res Inst, Adv Mat Lab, Madras 600020, Tamil Nadu, India
[4] VIT Univ, Ctr Biomat Cellular & Mol Theranost, Vellore, Tamil Nadu, India
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2019年 / 121卷
关键词：
Chitosan; Beta-glycerophosphate; Thermoresponsive hydrogel; Bone; Tissue engineering; MESENCHYMAL STEM-CELLS; BETA-TRICALCIUM PHOSPHATE; IN-VITRO; DRUG-DELIVERY; OSTEOGENIC DIFFERENTIATION; THERMOSENSITIVE HYDROGELS; BIOCOMPOSITE SCAFFOLDS; ALKALINE-PHOSPHATASE; RESPONSIVE HYDROGELS; SUSTAINED-RELEASE;
D O I：
10.1016/j.ijbiomac.2018.10.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tissue engineering (TE) is a promising approach for repairing diseased and damaged bone tissue. Injectable hydrogel based strategies offer a wide range of applications in rapid recovery of bone defects by acting as filler materials and depots for delivering various bioactive molecules and averting the need for surgical intervention. Chitosan (CS), a natural polysaccharide. forms a thermosensitive injectable hydrogel through the addition of beta-glycerophosphate (beta-GP). This hybrid hydrogel possesses numerous advantages namely mimicking native extracellular matrix (ECM) and providing an amenable microenvironment for cell growth. In this review, a brief insight into the gelation mechanism of CS/GP hydrogels, modifications, bioactive additives and their applications in treating bone defects are presented. (C) 2018 Elsevier B.V. All rights reserved.
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收藏
页码：38 / 54
页数：17
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