Genetic double knockout of cxcr4 and ccr5 chemokine receptors prevents neuronal cell death induced by HIV-1 gp120 upstream of p38 mitogen-activated protein kinase

被引:0
|
作者
Kaul, Marcus [1 ]
Medders, Kathryn E. [1 ]
Desai, Maya K. [1 ]
Lipton, Stuart A. [1 ]
机构
[1] Burnham Inst, Ctr Neurosci & Aging, La Jolla, CA 92037 USA
关键词
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:113 / 113
页数:1
相关论文
共 35 条
  • [1] Models of HIV-1 gp120 Complexed with CXCR4 and CCR5
    Agarwal, A.
    Stein, R. A.
    Cardozo, T.
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2013, 29 (11) : A82 - A83
  • [2] gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors
    Catani, MV
    Corasaniti, MT
    Navarra, M
    Nisticò, G
    Finazzi-Agrò, A
    Melino, G
    [J]. JOURNAL OF NEUROCHEMISTRY, 2000, 74 (06) : 2373 - 2379
  • [3] Inflammatory activation of microglia and macrophages by HIV-1 envelope protein gp120 via chemokine receptors CCR5 and CXCR4 stimulates p38MAP kinase and toxicity in neurons
    Kaul, Marcus
    Medders, Kathryn
    Desai, Maya
    Maung, Ricky
    Ma, Qing
    [J]. NEURON GLIA BIOLOGY, 2007, 2 : S112 - S112
  • [4] Evidence that CCR5 and CXCR4 chemokine receptors are involved in the mechanisms of HIV-1 GP120-induced apoptosis in the neocortex of rat
    Corasaniti, MT
    Strongoli, MC
    Piccirilli, S
    Nisticò, R
    Finazzi-Agrò, A
    Bagetta, G
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2000, 129
  • [5] Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
    Hesselgesser, J
    Taub, D
    Baskar, P
    Greenberg, M
    Hoxie, J
    Kolson, DL
    Horuk, R
    [J]. CURRENT BIOLOGY, 1998, 8 (10) : 595 - 598
  • [6] CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface
    Martinez-Munoz, Laura
    Barrosoa, Ruben
    Dyrhaug, Sunniva Y.
    Navarro, Gemma
    Lucas, Pilar
    Soriano, Silvia F.
    Vega, Beatriz
    Costas, Coloma
    Angeles Munoz-Fernandez, M.
    Santiago, Cesar
    Rodriguez Frade, Jose Miguel
    Franco, Rafael
    Mellado, Mario
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (19) : E1960 - E1969
  • [7] Neuronal apoptosis induced by HIV-1 gp120 and α-chemokine SDF-1 is attenuated by β-chemokines and p38 MAP Kinase inhibitors
    Kaul, M
    Lipton, SA
    [J]. NEUROLOGY, 2000, 54 (07) : A252 - A253
  • [8] HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Liu, QH
    Williams, DA
    McManus, C
    Baribaud, F
    Doms, RW
    Schols, D
    De Clercq, E
    Kotlikoff, MI
    Collman, RG
    Freedman, BD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) : 4832 - 4837
  • [9] Chemokine receptor CCR5 and CXCR4 down-modulation induced by cognate ligands and HIV gp120 is regulated by the proteasome pathway.
    Fernandis, A
    Cherla, RP
    Chernock, R
    Ganju, RK
    [J]. BLOOD, 2001, 98 (11) : 786A - 786A
  • [10] HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection
    M Kaul
    Q Ma
    K E Medders
    M K Desai
    S A Lipton
    [J]. Cell Death & Differentiation, 2007, 14 : 296 - 305