Evaluation of Glycopyrrolate as an Anticholinergic in Buffalo Calves (Bubalus bubalis)

Twelve experimental trials were undertaken on clinically healthy male buffalo calves. Glycopyrrolate was injected @ 0.01 mg/kg, IM. After glycopyrrolate administration, two animals became ataxic. Muzzle, mouth and nostrils became dry after 41.5 +/- 3.334 minute of drug administration; the same again became wet at 578.8 +/- 19.27 minute. The pulse pressure increased significantly after glycopyrrolate administration without any significant variation in heart rate, mean arterial pressure (MAP) and central venous pressure (CVP).