The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015

被引：180
|
作者：
Jagust, William J. [1 ]
Landau, Susan M. [1 ]
Koeppe, Robert A. [2 ]
Reiman, Eric M. [3 ]
Chen, Kewei [3 ]
Mathis, Chester A. [4 ]
Price, Julie C. [4 ]
Foster, Norman L. [5 ]
Wang, Angela Y. [5 ]
机构：
[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
[2] Univ Michigan, Dept Radiol, Div Nucl Med, Ann Arbor, MI 48109 USA
[3] Banner Alzheimer Inst, Phoenix, AZ USA
[4] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA
[5] Univ Utah, Ctr Alzheimers Care Imaging & Res, Dept Neurol, Salt Lake City, UT USA
来源：
ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 07期
关键词：
PET imaging; Amyloid; Fluorodeoxyglucose; Mild cognitive impairment; Alzheimer's disease; MILD COGNITIVE IMPAIRMENT; WHITE-MATTER REFERENCE; AMYLOID-BETA; HYPOTHETICAL MODEL; BIOMARKERS; TAU; MODERATE; PATHOLOGY; C-11-PIB; VOLUME;
D O I：
10.1016/j.jalz.2015.05.001
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction: This article reviews the work done in the Alzheimer's Disease Neuroimaging Initiative positron emission tomography (ADNI PET) core over the past 5 years, largely concerning techniques, methods, and results related to amyloid imaging in ADNI. Methods: The PET Core has used [F-18]florbetapir routinely on ADNI participants, with over 1600 scans available for download. Four different laboratories are involved in data analysis, and have examined factors such as longitudinal florbetapir analysis, use of [F-18]fluorodeoxyglucose (FDG)-PET in clinical trials, and relationships between different biomarkers and cognition. Results: Converging evidence from the PET Core has indicated that cross-sectional and longitudinal florbetapir analyses require different reference regions. Studies have also examined the relationship between florbetapir data obtained immediately after injection, which reflects perfusion, and FDG-PET results. Finally, standardization has included the translation of florbetapir PET data to a centiloid scale. Conclusion: The PET Core has demonstrated a variety of methods for the standardization of biomarkers such as florbetapir PET in a multicenter setting. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：757 / 771
页数：15
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