Autoimmune response to U1 small nuclear ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection

被引：50
|
作者：
Newkirk, MM
van Venrooij, WJ
Marshall, GS
机构：
[1] McGill Univ, Montreal Childrens Hosp, Div Rheumatol, Montreal, PQ H3H 1P3, Canada
[2] Univ Nijmegen, Dept Biochem, Nijmegen, Netherlands
[3] Univ Louisville, Sch Med, Dept Pediat, Louisville, KY 40292 USA
来源：
ARTHRITIS RESEARCH | 2001年 / 3卷 / 04期
关键词：
autoantibodies; cytomegalovirus; spliceosome; systemic lupus erythematosus;
D O I：
10.1186/ar310
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The induction of autoantibodies to U1 small nuclear ribonucleoprotein (U1 snRNP) complexes is not well understood. We present evidence that healthy individuals with cytomegalovirus (CMV) infection have an increased frequency and quantity of antibodies to ribonucleoprotein, directed primarily against the U1-70k protein. A significant association between the presence of antibodies to CMV and antibodies to the total RNP targeted by the immune response to the spliceosome (to both the Sm and RNP; Sm/RNP) was found for patients with systemic lupus erythematosus (SLE) but not those with mixed connective-tissue disease. CMV thus may play a role in inducing autoimmune responses in a subset of patients with systemic lupus erythematosus.
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页码：253 / 258
页数：6
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