Dissociable Effects of Theta-Burst Repeated Transcranial Magnetic Stimulation to the Inferior Frontal Gyrus on Inhibitory Control in Nicotine Addiction

被引:23
|
作者
Newman-Norlund, Roger D. [1 ]
Gibson, Makayla [1 ]
McConnell, Patrick A. [2 ]
Froeliger, Brett [2 ,3 ]
机构
[1] Univ South Carolina, Dept Psychol, Columbia, SC 29208 USA
[2] Med Univ South Carolina, Dept Neurosci, Charleston, SC 29425 USA
[3] Med Univ South Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA
来源
FRONTIERS IN PSYCHIATRY | 2020年 / 11卷
关键词
fMRI; TBS; TMS; tobacco; inhibition; executive; brain; cognition; SUPPLEMENTARY MOTOR AREA; SMOKING ABSTINENCE; EXECUTIVE CONTROL; SMOKERS; NETWORK; CORTEX; VARENICLINE; ACTIVATION; NONSMOKERS; ATTENTION;
D O I
10.3389/fpsyt.2020.00260
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Nicotine addiction, like other substance use disorders (SUD's), is associated with deficits in prefrontal mediated inhibitory control. The strength of inhibitory control task-based functional connectivity (tbFC) between the right inferior frontal gyrus (r.IFG) and thalamus (corticothalamic circuit) mediates the association between successful inhibition and smoking relapse vulnerability. However, the potential efficacy of theta burst stimulation (TBS) to the r.IFG, a treatment known to alter clinical symptoms among neuropsychiatric patients, has not been reported in a SUD population. This study utilized fMRI guided neuronavigation to examine the effects of TBS on inhibitory control among nicotine dependent individuals. Participants (N=12) were scanned while performing an inhibitory control task known to elicit inhibition-related activity in the r.IFG. Using a randomized, counterbalanced cross-over design, participants then received TBS over two visits: excitatory (iTBS) on one visit and inhibitory (cTBS) TBS on the other visit. The effects of each TBS condition on subsequent inhibitory control task performance were examined. A significant condition x time interaction was identified on trials requiring inhibitory control (F (1,10) = 7.27, p = .022, D = 1.63). iTBS improved inhibitory control, whereas cTBS impaired inhibitory control. Brain stimulation did not influence performance in control conditions including novelty detection and response execution. This is the first study to demonstrate that non-invasive neural stimulation using iTBS to the r.IFG enhances baseline inhibitory control among individuals with a SUD. Further research is needed to directly examine the potential parametric effects of TBS on corticothalamic tbFC in individuals with a SUD.
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页数:8
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