Synthesis of the branched C-glycoside substructure of altromycin B

被引：47
|
作者：
Koo, B [1 ]
McDonald, FE [1 ]
机构：
[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 17期
关键词：
D O I：
10.1021/ol050975u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Tungsten-catalyzed cycloisomerization of alkynyl alcohols including 8 provides only the endocyclic enol ether (11) as a key intermediate for the branched C-glycoside substructure (2) of altromycin B. A sequence of Stille cross-coupling reaction and regio- and stereoselective functional group transformations affords each C13-diastereomer of the branched C-arylglycoside (2a and 2b).
引用
收藏
页码：3621 / 3624
页数：4
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