Synthesis of glycose-containing amino acid derivatives

被引：0

作者：

Qian, Zhao-Sheng ^{[1
]}

Zhou, Chuan-Jian ^{[2
]}

Li, Gen ^{[1
]}

Cao, Ling-Hua ^{[1
]}

机构：

[1] Xinjiang Univ, Coll Chem & Chem Engn, Urumqi 830046, Peoples R China

[2] Shandong Univ, Sch Mat Sci & Technol, Jinan 250061, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 28卷 / 03期

关键词：

glycosyl isothiocyanate; L-alpha-amino acid; hydrazide; synthesis;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fifteen target compounds were synthesized with the following three steps: amino acids were protected to form carbobenzoxyamino acid methyl esters, the carbobenzoxyamino acid methyl esters reacted with hydrazine to give carbobenzoxy amino acid hydrazides, and treatment of the carbobenzoxy amino acid hydrazides with glycosyl isothiocyanates afforded 3a similar to 3o in 65%similar to 86% yields. All the new compounds were characterized by elemental analysis, MS, IR and H-1 NMR spectra. Besides, the optimal reaction condition of the hydrazinolysis of carbobenzoxyamino acid methyl esters was studied.

引用

页码：467 / 471

页数：5

共 16 条

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