Cytokine profiles in a cohort of long-term survivors of transfusion-acquired HIV-1 infection

被引：0

作者：

Geczy, AF ^{[1
]}

Blasdall, SA ^{[1
]}

Raynes-Greenow, C ^{[1
]}

Dyer, WB ^{[1
]}

Learmont, JC ^{[1
]}

Sullivan, JS ^{[1
]}

McIntyre, LB ^{[1
]}

机构：

[1] Australian Red Cross Blood Serv, Sydney, NSW, Australia

来源：

10TH INTERNATIONAL CONGRESS ON IMMUNOLOGY, VOLS 1 AND 2 | 1998年

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since the identification of HIV-1 in blood products during the mid 1980s, 134 individuals with transfusion-acquired HIV-1 have been uncovered by the Australian Red Cross Blood Service-New South Wales Lookback programme. During the course of tracing, a unique group of recipients was identified with their common donor; all have remained asymptomatic. This group, known as the Sydney Blood Bank Cohort (SBBC), has shared nef/LTR deletions in the HIV-1 genome. Cytokine mRNA levels in members of the SBBC were compared with individuals with sexually-acquired HIV-1 infection and with transfusion-matched HIV-l-negative controls. We found that the level of cytokine mRNA from members of the SBBC was similar to or better than those of some sexually-acquired HIV-l-positive long-term non-progressors (LTNP), including the matched control groups. On the basis of their cytokine profiles, the immune response of the SBBC is similar to that of normal individuals.

引用

页码：1135 / 1139

页数：5