Synthesis and biological activity of novel 1H-1,4-diazepines containing benzene sulfonyl piperazine moiety

The synthesis of biologically active 1H-1,4-diazepines 6a-e in good yield, from the heterocyclization reaction of [N (4)-(4-acetylamino) benzene sulfonyl) piperazinyl-N (1)-propyl]-1,3-dialkyl/aryl propane-1,3-dione 5a-e and ethylenediamine (EDA) in the presence of silica sulphuric acid (SSA) is described. The novel beta-diketones/beta-ketoesters 5a-e were synthesized by the condensation reaction of [N (4)-(4-acetylamino) benzene sulfonyl) piperazinyl-N (1)-1-bromopropane with various beta-diketones/beta-ketoesters 4a-e. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral studies. The compounds 6a-e have been screened for antimicrobial, antifungal and anthelmintic activity.