Waste activated sludge (WAS) is commonly treated by using anaerobic digestion (AD), which has the advantage of reducing sludge volumes and generating methane. However, the sludge structure limits the efficiency of these AD processes. In fact, most of the organic substance found in sludge is surrounded by cell walls or bound in complex structures [extracellular polymeric substance (EPS)] and can only be made ready for digestion after intense hydrolysis processes. This paper presents the preliminary results of tests carried out to compare the performances of pretreatments and intermediate treatments. They were both performed using a hybrid modality, that is, by combining an alkali agent and heat. Hybrid treatments at low doses [4-8% of the total soid (TS) matrix] of NaOH and Ca(OH)(2) were carried out on WAS and on already digested sludge. Batch mesophilic digestion tests were used to assess the methane specific production of samples of WAS and digestate before and after lysis treatment. Digestibility tests revealed a specific methane yield of respectively 0.166 and 0.143 Nm(3)/kg VSadded for raw WAS and digestate. The production of methane for the WAS sample increased by 40 and 66% when it was treated at 70 and 90 degrees C, respectively, in combination with a NaOH dose of 4 g/100 g TS. Intermediate treatments carried out under the same operating conditions caused increases in the specific production of methane of 31% (70 degrees C) and 54% (90 degrees C), respectively, for the samples of already digested sludge. Using these results, it was calculated that if the digestion process was carried out in two steps, with a duration of 10 days each, the production of methane could increase by 27 and 17% (at 70 and 90 degrees C), respectively, compared with the scenario that only used the pretreatment processes. (C) 2017 American Society of Civil Engineers.