Natural frozen embryo transfer with hCG booster leads to improved cycle outcomes: a retrospective cohort study

被引:10
|
作者
Reichman, David E. [1 ]
Stewart, Claire R. [1 ]
Rosenwaks, Zev [1 ]
机构
[1] Weill Cornell Med Ctr, Ronald O Perelman & Claudia Cohen Ctr Reprod Med, 1305 York Ave, New York, NY 10021 USA
关键词
Frozen embryo transfer; hCG; Luteal phase support; Natural cycle; IMPLANTATION;
D O I
10.1007/s10815-020-01740-7
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Purpose To determine whether luteal support with intramuscular injection of human chorionic gonadotropin 1 day post-LH surge in natural cycle frozen embryo transfer (nFETs) increases ongoing pregnancy rates (OPR). Methods Retrospective cohort study of women who underwent natural cycle FET with transfer of a single day-5 or - 6 euploid blastocyst between January 2017 and December 2018 at an academic medical center were divided into two groups based on whether they received hCG 1 day post-LH surge. Patients with uterine factor infertility were excluded. Results A total of 529 nFET cycles were included. The OPR was significantly higher in the treatment group than in the non-treatment group when controlling for potential confounders such as embryo morphology (69.9% versus 57.4%, p = 0.0119, aOR1.724, 95% CI 1.13-2.65). There were no significant differences observed in the rates of first trimester loss (aOR 1.05, 95% CI 0.032-2.96) or biochemical pregnancy (aOR 0.79, 95% CI 0.31-1.76). Odds ratios were adjusted for patient's age, body mass index, peak endometrial thickness, gravidity, and parity. Conclusion The current data suggest that the hCG booster given to patients within 1 day post-LH surge results in improved cycle outcomes compared to patients who do not receive the booster.
引用
收藏
页码:1177 / 1182
页数:6
相关论文
共 50 条
  • [1] Natural frozen embryo transfer with hCG booster leads to improved cycle outcomes: a retrospective cohort study
    David E. Reichman
    Claire R. Stewart
    Zev Rosenwaks
    [J]. Journal of Assisted Reproduction and Genetics, 2020, 37 : 1177 - 1182
  • [2] NATURAL FROZEN EMBRYO TRANSFER WITH HCG BOOSTER FOR OPTIMIZATION OF CYCLE OUTCOMES: A RETROSPECTIVE COHORT STUDY.
    Stewart, Claire
    Reichman, David
    Rosenwaks, Zev
    [J]. FERTILITY AND STERILITY, 2019, 112 (03) : E174 - E174
  • [3] Pregnancy outcomes of four different cycle protocols for frozen embryo transfer: a large retrospective cohort study
    Qian Yue
    Wan Qi
    Bu XiaoQing
    Li Tian
    Tang XiaoJun
    Jia Yan
    Feng Qian
    Lv XingYu
    Meng XiangQian
    Yang Yin
    Ding YuBin
    Geng LiHong
    Xia Min
    Zhong ZhaoHui
    [J]. 生殖与发育医学(英文)., 2023, 07 (03)
  • [4] Pregnancy outcomes of four different cycle protocols for frozen embryo transfer: a large retrospective cohort study
    Qian, Yue
    Wan, Qi
    Bu, Xiao-Qing
    Li, Tian
    Tang, Xiao-Jun
    Jia, Yan
    Feng, Qian
    Lv, Xing-Yu
    Meng, Xiang-Qian
    Yang, Yin
    Ding, Yu-Bin
    Geng, Li-Hong
    Xia, Min
    Zhong, Zhao-Hui
    [J]. REPRODUCTIVE AND DEVELOPMENTAL MEDICINE, 2023, 7 (03) : 135 - 141
  • [5] Luteal phase progesterone supplementation following induced natural cycle frozen embryo transfer: A retrospective cohort study
    Schwartz, Emilie
    Bernard, Laure
    Ohl, Jeanine
    Bettahar, Karima
    Rongieres, Catherine
    Lichtblau, Isabelle
    Pirrello, Olivier
    [J]. JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, 2019, 48 (02) : 95 - 98
  • [6] Endometrial preparation methods prior to frozen embryo transfer: A retrospective cohort study comparing true natural cycle, modified natural cycle and artificial cycle
    Mensing, Lena
    Dahlberg, Emilie S.
    Bay, Bjorn
    Gabrielsen, Anette
    Knudsen, Ulla B.
    [J]. ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2022, 306 (04) : 1381 - 1388
  • [7] Endometrial preparation methods prior to frozen embryo transfer: A retrospective cohort study comparing true natural cycle, modified natural cycle and artificial cycle
    Lena Mensing
    Emilie S. Dahlberg
    Bjørn Bay
    Anette Gabrielsen
    Ulla B. Knudsen
    [J]. Archives of Gynecology and Obstetrics, 2022, 306 : 1381 - 1388
  • [8] Natural cycle for frozen-thawed embryo transfer: Spontaneous ovulation or triggering by HCG
    Huberlant, S.
    Vaast, M.
    Anahory, T.
    Tailland, M. L.
    Rougier, N.
    Ranisavljevic, N.
    Hamamah, S.
    [J]. GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE, 2018, 46 (05): : 466 - 473
  • [9] Reproductive and Obstetric Outcomes Following a Natural Cycle vs. Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer: A Retrospective Cohort Study
    Carosso, Andrea Roberto
    Brunod, Nicole
    Filippini, Claudia
    Revelli, Alberto
    Evangelisti, Bernadette
    Cosma, Stefano
    Borella, Fulvio
    Canosa, Stefano
    Benedetto, Chiara
    Gennarelli, Gianluca
    [J]. JOURNAL OF CLINICAL MEDICINE, 2023, 12 (12)
  • [10] Letrozole-induced endometrial preparation improved the pregnancy outcomes after frozen blastocyst transfer compared to the natural cycle: a retrospective cohort study
    Kenji Ezoe
    Junichiro Fukuda
    Kazumi Takeshima
    Kazunori Shinohara
    Keiichi Kato
    [J]. BMC Pregnancy and Childbirth, 22