Do matrix metalloproteinases MMP-2 and MMP-9 (gelatinases) play a role in renal development, physiology and glomerular diseases?

被引：70
|
作者：
Lelongt, B
Legallicier, B
Piedagnel, R
Ronco, PN
机构：
[1] Hop Tenon, Div Renal, F-75020 Paris, France
[2] Hop Tenon, INSERM, U489, Assistance Publ Hop Paris, F-75020 Paris, France
[3] Univ Paris 06, Hop Tenon, Assistance Publ Hop Paris, Paris, France
来源：
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2001年 / 10卷 / 01期
关键词：
D O I：
10.1097/00041552-200101000-00002
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Metalloproteinases MMP-2 and MMP-9 (also called gelatinases) are involved in cell invasion and in embryonic development and organogenesis. A growing number of reports suggest that MMP-2 and MMP-9 play some role in renal development, renal tubule physiology and glomerular pathophysiology. This editorial will focus on recent controversial data, especially those obtained from studies on MMP-9- deficient mice, which shed new light on the functions of gelatinases in normal and diseased kidneys. Curr Opin Nephrol Hypertens 10:7-12. (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：7 / 12
页数：6
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