Successful treatment of immune thrombocytopenic purpura (ITP) with the thrombopoietin-mimetic Romiplostim

被引：0
|
作者：
Meletis, John [1 ]
Katsandris, Aikaterini [1 ]
Raptis, Sophia D. [1 ]
Mantzourani, Marina [1 ]
机构：
[1] Univ Athens, Dept Internal Med 1, Sch Med, Laikon Gen Hosp, Athens 11528, Greece
来源：
MEDICAL SCIENCE MONITOR | 2010年 / 16卷 / 08期
关键词：
immune thrombocytopenic purpura; ITP; megakaryopoiesis; thrombopoietin; TPO; romiplostim; treatment; EFFICACY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Romiplostim is a second-generation thrombopoietic receptor agonist that exerts its therapeutic effect by stimulating megakaryopoiesis. Case Report: We report a patient with immune thrombocytopenic purpura refractory to other therapies including splenectomy, which was successfully managed with romiplostim. More specifically, the patient's platelet count showed a 3-fold increase within 7 days following the first dose of romiplostim (from 33x10(9)/l to 96x10(9)/l). Conclusions: Romiplostin is a new trombopoietin peptide mimetic drug, which seems to be very effective for the management of refractory chronic ITP in adults.
引用
收藏
页码：CS100 / CS102
页数：3
相关论文
共 50 条
  • [1] EFFICACY AND SAFETY OF SUCCESSFUL TREATMENT IMMUNE THROMBOCYTOPENIC PURPURA (ITP) WITH THE THROMBOPOIETIN-MIMETIC ROMIPLOSTIM
    Mantzourani, M.
    Katsandris, A.
    Ntziora, F.
    Tsifis, J.
    Vaiopoulos, G.
    Meletis, J.
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 : 751 - 751
  • [2] Long-Term Use of the Thrombopoietin-Mimetic Romiplostim in Children With Severe Chronic Immune Thrombocytopenia (ITP)
    Bussel, James B.
    Hsieh, Loan
    Buchanan, George R.
    Stine, Kimo
    Kalpatthi, Ram
    Gnarra, David J.
    Ho, Richard H.
    Nie, Kun
    Eisen, Melissa
    [J]. PEDIATRIC BLOOD & CANCER, 2015, 62 (02) : 208 - 213
  • [3] Thrombopoietin mimetic agents in the management of immune thrombocytopenic purpura
    Newland, Adrian
    [J]. SEMINARS IN HEMATOLOGY, 2007, 44 (04) : S35 - S45
  • [4] Impact Assessment of Immunogenicity of Romiplostim In Subjects with Immune Thrombocytopenic Purpura (ITP).
    Pamma, Rupinderjit
    Deshpande, Meghana
    Hokom, Martha
    Gupta, Shalini
    Zhuang, Yao
    Chirmule, Naren
    Swanson, Steve
    Jawa, Vibha
    [J]. BLOOD, 2010, 116 (21) : 1043 - 1043
  • [5] Use of a Thrombopoietin Mimetic for Chronic Immune Thrombocytopenic Purpura in Pregnancy
    Patil, Avinash S.
    Dotters-Katz, Sarah K.
    Metjian, Ara D.
    James, Andra H.
    Swamy, Geeta K.
    [J]. OBSTETRICS AND GYNECOLOGY, 2013, 122 (02): : 483 - 485
  • [6] Thrombopoietin Receptor Agonist in Pregnancy: a Case For Romiplostim in Refractory Immune Thrombocytopenic Purpura
    Chukwuemeka C. Uzoka
    Darla K. Liles
    [J]. SN Comprehensive Clinical Medicine, 4 (1)
  • [7] Romiplostim: a breakthrough treatment for the management of immune thrombocytopenic purpura
    Newland, Adrian
    [J]. EUROPEAN JOURNAL OF HAEMATOLOGY, 2009, 82 : 20 - 25
  • [8] Romiplostim for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura
    Jamali, Faranak
    Lemery, Steven
    Ayalew, Kassa
    Robottom, Suzanne
    Robie-Suh, Kathy
    Rieves, Dwaine
    Pazdur, Richard
    [J]. ONCOLOGY-NEW YORK, 2009, 23 (08): : 704 - 709
  • [9] COST-EFFECTIVENESS ANALYSIS OF ROMIPLOSTIM FOR THE TREATMENT OF ADULT CHRONIC IMMUNE THROMBOCYTOPENIC PURPURA (ITP) IN BRAZIL
    dos Santos, R. F.
    Vargas-Valencia, J. J.
    Giannopoulou, A.
    Campioni, M.
    [J]. VALUE IN HEALTH, 2015, 18 (07) : A668 - A668
  • [10] LONGER-TERM USE OF THE THROMBOPOIETIN-MIMETIC PEPTIBODY ROMIPLOSTIM IN CHILDREN WITH CHRONIC/REFRACTORY IMMUNE THROMBOCYTOPENIA (ITP): RESULTS OF AN OPEN-LABEL EXTENSION STUDY
    Nugent, Diane
    Bussel, James
    Buchanan, George
    Stine, Kimo
    Kalpatthi, Ramasubramanian
    Nie, Kun
    Eisen, Melissa
    [J]. PEDIATRIC BLOOD & CANCER, 2011, 56 (06) : 916 - 916
12345